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001-es BibID:	BIBFORM092976
Első szerző:	Gebri Enikő Zsuzsa (fogszakorvos)
Cím:	Salivary Osteopontin as a Potential Biomarker for Oral Mucositis / Enikő Gebri, Attila Kiss, Ferenc Tóth, Tibor Hortobágyi
Dátum:	2021
Megjegyzések:	Abstract: Osteopontin (OPN), a multifunctional phosphoglycoprotein also presents in saliva, plays a crucial role in tumour progression, inflammation and mucosal protection. Mucosal barrier injury due to high-dose conditioning regimen administered during autologous and allogeneic peripheral stem cell transplantation (APSCT) has neither efficient therapy nor established biomarkers. Our aim was to assess the biomarker role of OPN during APSCT, with primary focus on oral mucositis (OM). Serum and salivary OPN levels were determined by ELISA in 10 patients during APSCT at four stages of transplantation (day ??3/??7, 0, +7, +14), and in 23 respective healthy controls. Results: There was a negative correlation between both salivary and serum OPN levels and grade of OM severity during APSCT (r = ??0.791, p = 0.019; r = ??0.973, p = 0.001). Salivary OPN increased at days +7 (p = 0.011) and +14 (p = 0.034) compared to controls. Among patients, it was higher at day +14 compared to the time of admission (day ??3/??7) (p = 0.039) and transplantation (day 0) (p = 0.011). Serum OPN remained elevated at all four stages of transplantation compared to controls (p = 0.013, p = 0.02, p = 0.011, p = 0.028). During APSCT elevated salivary OPN is a potential non-invasive biomarker of oral mucositis whereas the importance of high serum OPN warrants further studies.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Metabolites. - 11 : 4 (2021), p. 1-16. -
További szerzők:	Kiss Attila (1942-) (belgyógyász, haematológus) Tóth Ferenc (fogorvos) Hortobágyi Tibor (1965-) (patológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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