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001-es BibID:	BIBFORM093908
035-os BibID:	(WoS)000645510200001 (Scopus)85105351576
Első szerző:	Balogh Eszter (neurológus)
Cím:	Effects of acute alcohol consumption on neuronal activity and cerebral vasomotor response / Balogh Eszter, Árokszállási Tamás, Körtefái Katalin, Nagy Veronika Éva, Csiba László, Oláh László
Dátum:	2022
ISSN:	1590-1874
Megjegyzések:	Introduction In the majority of European countries, driving after drinking small-moderate amount of alcohol is legal. Motivated by our previous studies on cerebral hemodynamics, we aimed to study whether a small-moderate blood alcohol content (BAC), at which driving is legal in some countries (0.8 g/L), influences the neuronal activity, neurovascular coupling, and cerebral vasoreactivity. Methods Analyses of pattern-reversal visual evoked potential (VEP) and transcranial Doppler (TCD) examinations were performed in thirty young healthy adults before and 30 min after alcohol consumption. Cerebral vasoreactivity was evaluated by breath holding test in both middle cerebral arteries. By using a visual cortex stimulation paradigm, visually evoked flow velocity response during reading was measured in both posterior cerebral arteries (PCA). Results The BAC was 0.82 g/L and 0.94 g/L 30 and 60 min after drinking alcohol, respectively. Latency of the VEP P100 wave increased after alcohol consumption. Resting absolute flow velocity values increased, whereas pulsatility indices in the PCA decreased after alcohol ingestion, indicating vasodilation of cerebral microvessels. Breath holding index and the visually evoked maximum relative flow velocity increase in the PCA and steepness of rise of the flow velocity curve were smaller after than before alcohol consumption. Conclusion BAC close to a legal value at which driving is allowed in some European countries inhibited the neuronal activity and resulted in dilation of cerebral arterioles. Cerebral vasodilation may explain the decrease of cerebral vasoreactivity and might contribute to the disturbance of visually evoked flow response after alcohol consumption.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Acute alcohol consumption Cerebral vasoreactivity Neurovascular coupling Transcranial Doppler Visual activation
Megjelenés:	Neurological Sciences. - 43 : 1 (2022), p. 625-631. -
További szerzők:	Árokszállási Tamás (1988-) (neurológus) Körtefái Katalin Nagy Veronika Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:	Nemzeti Agykutatási Program (NAP_13-1-2013-0001) Egyéb Nemzeti Agykutatási Program (2017-1.2.1-NKP-2017-00002) Egyéb GINOP-2.3.2-15-2016-00043 GINOP MTA-DE Cerebrovascular and Neurodegenerative Research Group MTA
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