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001-es BibID:	BIBFORM095593
035-os BibID:	(Scopus)85109072246 (WoS)000668383100001
Első szerző:	Unfer, Vittorio
Cím:	Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy : a matter of molecular weight / Unfer Vittorio, Tilotta Marco, Kaya Cihan, Noventa Marco, Török Péter, Alkatout Ibrahim, Gitas Georgios, Bilotta Gabriele, Laganà Antonio Simone
Dátum:	2021
ISSN:	1742-5255
Megjegyzések:	Introduction For many years hyaluronic acid (HA) was mainly used for its hydrating properties. However, new applications have recently arisen, considering the biological properties of HA and its molecular weight. Clinical application of low molecular weight HA (LMW-HA) initially was supported by specific absorption data. The identification of high molecular weight HA (HMW-HA) absorption pathways and the knowledge of its physiological role allowed to evaluate its clinical application. Based on the immunomodulatory properties of HMW-HA and its physiological involvement as signaling molecule, pregnancy represents an interesting context of application. Area covered This expert opinion includes in-vitro, in-vivo, ex-vivo and clinical studies on gestational models. It provides an overview of the physiological and the therapeutic role of HMW-HA in pregnancy starting from its metabolism. Indeed, HMW-HA is widely involved in several physiological processes as implantation, immune response, uterine quiescence and cervical remodeling, and therefore is an essential molecule for a successful pregnancy. Expert opinion Available evidence suggests that HMW-HA administration can support physiological pregnancy, favoring blastocyst adhesion and development, preventing miscarriage and pre-term birth. For this reason, supplementation in pregnancy should be evaluated.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Hyaluronic acid high-molecular-weight hyaluronic acid absorption pregnancy recurrent miscarriage preeclampsia pre-term birth
Megjelenés:	Expert Opinion on Drug Metabolism & Toxicology. - 17 : 7 (2021), p. 823-840. -
További szerzők:	Tilotta, Marco Kaya, Cihan Noventa, Marco Török Péter (1975-) (szülész-nőgyógyász) Alkatout, Ibrahim Gitas, Georgios Bilotta, Gabriele Laganà, Antonio Simone
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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