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001-es BibID:	BIBFORM095727
Első szerző:	Shi, Xiangyang
Cím:	Electrophoretic mobility and molecular distribution studies of poly(amidoamine) dendrimers of defined charges / Xiangyang Shi, István Bányai, Keyla Rodriguez, Mohammad T. Islam, Wojciech Lesniak, Peter Balogh, Lajos P. Balogh, James R. Baker
Dátum:	2006
ISSN:	0173-0835 1522-2683
Megjegyzések:	Generation 5 ethylenediamine (EDA)-cored poly(amidoamine) (PAMAM) dendrimers(E5, E d enotes the EDA core and 5 the generation number) with different degrees of acetylation and carboxylation were synthesized and used as a model system to investigate the effect of charge and the influence of dendrimer surface modifications on electrophoretic mobility (EM) and molecular distribution. The surface-modified dendrimers were characterized by size-exclusion chromatography, 1H NMR, MALDITOF-MS, PAGE, and CE. The focus of our study was to determine how EM changes as a function of particle charge and molecular mass, and how the molecular distribution changes due to surface modifications. We demonstrate that partially modified dendrimers have much broader migration peaks than those of fully surface functionalized or unmodified E5 dendrimers due to variations in the substitution of individual dendrimer surfaces. EM decreased nonlinearly with increases in surface acetylation for both PAMAM acetamides and PAMAM succinamic acids, indicating a complex migration activity in CE separations that is not solely due to charge/mass ratio changes. These studies provide new insights into dendrimer properties under an electric field, as well as into the characterization of dendrimer-based materials being developed for medical applications.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Capillary electrophoresis Electrophoretic mobility Molecular distribution Poly(amidoamine) dendrimers
Megjelenés:	Electrophoresis. - 27 : 9 (2006), p. 1758-1767. -
További szerzők:	Bányai István (1953-) (vegyész) Rodriguez, Keyla Islam, Mohammad T. Lesniak, Wojciech G. Balogh Péter Balogh Lajos P. Baker, James R.
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