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001-es BibID:	BIBFORM098737
035-os BibID:	(Scopus)85112314608 (WoS)000697690900032
Első szerző:	Magyar Ágnes (gyermeksebész)
Cím:	Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus / Magyar Agnes, Racz Eva, Matesz Clara, Wolf Ervin, Kiss Peter, Gaál Botond Ágoston
Dátum:	2022
ISSN:	1673-5374
Megjegyzések:	Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of processes such as modification in the efficacy of synaptic inputs. As the plasticity of adult central nervous system is associated with the alteration of extracellular matrix, including its condensed form, the perineuronal net, we studied the changes of brevican expression in the perineuronal nets of the superior vestibular nucleus after unilateral labyrinth lesion. Our results demonstrated that the unilateral labyrinth lesion and subsequent compensation are accompanied by the changing of brevican staining pattern in the perineuronal nets of superior vestibular nucleus of the rat. The reduction of brevican in the perineuronal nets of superior vestibular nucleus may contribute to the vestibular plasticity by suspending the non-permissive role of brevican in the restoration of perineuronal net assembly. After a transitory decrease, the brevican expression restored to the control level parallel to the partial restoration of impaired vestibular function. The bilateral changing in the brevican expression supports the involvement of commissural vestibular fibers in the vestibular compensation. All experimental procedures were approved by the ♭University of Debrecen ? Committee of Animal Welfare' (approval No. 6/2017/DEMAB) and the ♭Scientific Ethics Committee of Animal Experimentation' (approval No. HB/06/ÉLB/2270-10/2017; approved on June 6, 2017)
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk brainstem brevican chondroitin sulfate proteoglycan extracellular matrix labyrinth lesion neural plasticity perineuronal net perisynaptic matrix vestibular compensation vestibular system
Megjelenés:	Neural Regeneration Research. - 17 : 3 (2022), p. 649-654. -
További szerzők:	Rácz Éva (1982-) (biológus) Matesz Klára (1949-) (anatómus, neurobiológus) Wolf Ervin (1961-) (fizikus, neurobiológus) Kiss Péter Gaál Botond Ágoston (1982-) (anatómus, neurobiológus)
Pályázati támogatás:	K115471 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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