Találati lista | Tudóstér

001-es BibID:	BIBFORM098915
Első szerző:	Ríos, Eduardo (kutató)
Cím:	Excitation-contraction coupling in skeletal muscle / Eduardo Ríos, Adom González, Miloslav Karhanek, Jianjie Ma, Roman Shirokov, Gonzalo Pizarro, Laszlo Csernoch, Robert Fitts, Ismael Uribe, M. Marlene Hosey
Dátum:	1994
Megjegyzések:	A historical approach is a simple way for reviewing the background necessary for discussions of the current concerns. 1947 is a convenient starting point; in this field, as well as in others, a number of contributions appeared two to three years after the war, that defined the field for years to come. Heilbrunn and Wiercinski [1] essentially demonstrated Ca2+ to be the second messenger that controls contraction, and proposed that Ca2+ entered the myoplasm from outside; A.V. Hill [2] demonstrated, with a simple diffusion calculation, the need for a propagation mechanism of activation, other than diffusion from the outside. This system was identified in the fifties: in 1958 Huxley and Taylor [3] suceeded in depolarizing localized regions of the membrane of a fiber with an extracellular electrode placed very close to the fiber, a predecessor of patch clamp. The depolarization only induced contractions (localized to the underlying zone) when the pipette was placed over the I band, but not over the A band. It is interesting that C. Franzini ? Armstrong, when reviewing the field, always starts at this time. This result obviously motivated her, as it did other morphologists, to search for a structure underlying these localized effects. Her celebrated studies have a predecessor, closer to home, E. Veratti [4] who had described the T tubular system in 1902, using the Golgi staining technique. Apparently his contemporaries, when presented with the pictures, only said se non ℓe vero ℓe ben trovato, and ignored the result, wich was only exploited in the sixties and seventies by Franzini ? Armstrong [4 bis], B. Eisenberg [5], L. Peachey [6] and others. Figure 1 shows a view of a thick transversal cut of a fiber bundle, with Golgi stain (Peachey and Eisenberg [7]), demonstrating how the T system effectively reduces the (diffusion) distances in the transversal direction to under a micrometer. As the morphological description of the T system progressed, so did that of the sarcoplasmic reticulum (Sr).
ISBN:	978 0 306 44813 3
Tárgyszavak:	Orvostudományok Elméleti orvostudományok könyvfejezet könyvrészlet Sarcoplasmic Reticulum Release Channel Ryanodine Receptor Charge Movement Sarcoplasmic Reticulum Membrane
Megjelenés:	Bioelectrochemistry IV. / szerk. Bruno Andrea Melandri, Giulio Milazzo, Martin Blank. - p. 225-254. -
További szerzők:	González, Adom Karhanek, Miloslav Ma, Jianjie Shirokov, Roman Pizzaro, Gonzalo Csernoch László (1961-) (élettanász) Fitts, Robert Uribe, Ismael Hosey, M. Marlene
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: