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001-es BibID:BIBFORM099610
035-os BibID:(WoS)000752315000001 (Scopus)85122028458
Első szerző:Yuan, Jing-Zhe
Cím:Zizaane-Type Sesquiterpenoids and Their Rearranged Derivatives from Agarwood of an Aquilaria Plant / Jing-Zhe Yuan, Yi-Ling Yang, Wei Li, Li Yang, Hao-Fu Dai, Attila Mándi, Cai-Hong Cai, Hui-Qin Chen, Wen-Hua Dong, Tibor Kurtán, Wen-Li Mei, Hao Wang
Dátum:2022
ISSN:1420-3049
Megjegyzések:Nine new sesquiterpenoids (1-9) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp., including three novel sesquiterpenoids (1-3) derived from zizaane, together with six zizaane-type sesquiterpenoids (4-9). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of sesquiterpenoids was determined by comparison of the experimental and computed ECD spectra. In vitro anti-inflammatory assessment showed that compound 9 exhibited inhibition of NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 62.22 ? 1.27 ?M.
Nine new sesquiterpenoids (1-9) were isolated from ethyl ether extract of agarwood origi-nated from Aquilaria sp., including three novel sesquiterpenoids (1-3) derived from zizaane, together with six zizaane-type sesquiterpenoids (4-9). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of sesquiter-penoids was determined by comparison of the experimental and computed ECD spectra. In vitro anti-inflammatory assessment showed that compound 9 exhibited inhibition of NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 62.22 ± 1.27 ?M.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
agarwood
Aquilaria sp.
sesquiterpenoid
zizaane
TDDFT-ECD
anti-inflammatory effect
Megjelenés:Molecules. - 27 : 1 (2022), p. 1-14. -
További szerzők:Yang, Yi-Ling Li, Wei (1987-) (kutató) Yang, Li Dai, Haofu Mándi Attila (1981-) (vegyész, német szakfordító) Cai, Cai-Hong Chen, Huiqin Dong, Wen-Hua Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mei, Wen-Li Wang, Hao
Pályázati támogatás:NKFI K120181
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