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001-es BibID:	BIBFORM099767
035-os BibID:	(WoS)000737102800002 (Scopus)85122267234
Első szerző:	Llanaj, Erand (táplálkozási epidemiológus)
Cím:	Effect of oat supplementation interventions on cardiovascular disease risk markers : a systematic review and meta-analysis of randomized controlled trials / Llanaj Erand, Dejanovic Gordana M., Valido Ezra, Bano Arjola, Gamba Magda, Kastrati Lum, Minder Beatrice, Stojic Stevan, Voortman Trudy, Marques-Vidal Pedro, Stoyanov Jivko, Metzger Brandon, Glisic Marija, Kern Hua, Muka Taulant
Dátum:	2022
ISSN:	1436-6207
Megjegyzések:	Purpose Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms. Methods We included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers. Results Seventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) - 0.42 mmol/L, (- 0.61; - 0.22)], LDL cholesterol [- 0.29 mmol/L, (- 0.37; - 0.20)], glucose [- 0.25 nmol/L, (- 0.36; - 0.14)], body mass index [- 0.13 kg/m(2), (- 0.26; - 0.01)], weight [- 0.94 kg, (- 1.84: - 0.05)], and waist circumference [- 1.06 cm, (- 1.85; - 0.27)]. RCTs on inflammation and/or oxidative stress markers were scarce and with inconsistent findings. RCTs comparing an OSI to heterogeneous interventions (e.g., wheat, eggs, rice, etc.), showed lowered levels of glycated haemoglobin, diastolic blood pressure, HDL cholesterol and apolipoprotein B. The majority of included RCTs (81.1%) had some concerns for risk of bias. Conclusion Dietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Journal Of Nutrition. - 61 : 4 (2022), p. 1749-1778. -
További szerzők:	Dejanovic, Gordana M. Valido, Ezra Bano, Arjola Gamba, Magda Kastrati, Lum Minder, Beatrice Stojic, Stevan Voortman, Trudy Marques-Vidal, Pedro Stoyanov, Jivko Metzger, Brandon Glisic, Marija Kern, Hua Muka, Taulant
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