Találati lista | Tudóstér

001-es BibID:	BIBFORM099772
035-os BibID:	(WoS)000781667500004 (Scopus)85122618330
Első szerző:	Datki Zsolt
Cím:	The interacting rotifer-biopolymers are anti- and disaggregating agents for human-type beta-amyloid in vitro / Zsolt Datki, Evelin Balazs, Bence Galik, Rita Sinka, Lavinia Zeitler, Zsolt Bozso, János Kalman, Tibor Hortobagyi, Zita Galik-Olah
Dátum:	2022
ISSN:	0141-8130
Megjegyzések:	Neurodegeneration-related human-type beta-amyloid 1-42 aggregates (H-A?) are one of the biochemical markers and executive molecules in Alzheimer's disease. The exogenic rotifer-specific biopolymer, namely Rotimer, has a protective effect against H-A? toxicity on Euchlanis dilatata and Lecane bulla monogonant rotifers. Due to the external particle-dependent secreting activity of these animals, this natural exudate exists in a bound form on the surface of epoxy-metal beads, named as Rotimer Inductor Conglomerate (RIC). In this current work the experiential in vitro molecular interactions between Rotimer and A?s are presented. The RIC form was uniformly used against H-A? aggregation processes in stagogram- and fluorescent-based experiments. These well-known cell-toxic aggregates stably and quickly (only taking a few minutes) bind to RIC. The epoxy beads (as carriers) alone or the scrambled version of H-A? (with random amino acid sequence) were the ineffective and inactive negative controls of this experimental system. The RIC has significant interacting, anti-aggregating and disaggregating effects on H-A?. To detect these experiments, Bis-ANS and Thioflavin T were applied during amyloid binding, two aggregation-specific functional fluorescent dyes with different molecular characteristics. This newly described empirical interaction of Rotimer with H-A? is a potential starting point and source of innovation concerning targeted human- and pharmaceutical applications.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Journal Of Biological Macromolecules. - 201 (2022), p. 262-269. -
További szerzők:	Balázs Evelin Galik Bence Sinka Rita Zeitler, Lavinia Bozsó Zsolt Kálmán János Hortobágyi Tibor (1965-) (patológus) Galik-Oláh Zita
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: