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001-es BibID:	BIBFORM100001
035-os BibID:	(cikkazonosító)739 (Scopus)85123104849 (WOS)000742753500034
Első szerző:	Gecse Kinga
Cím:	Association of plasma tryptophan concentration with periaqueductal gray matter functional connectivity in migraine patients / Gecse Kinga, Dobos Dóra, Aranyi Csaba Sándor, Galambos Attila, Baksa Daniel, Kocsel Natália, Szabó Edina, Pap Dorottya, Virág Dávid, Ludányi Krisztina, Kökönyei Gyöngyi, Emri Miklós, Bagdy Gyorgy, Juhasz Gabriella
Dátum:	2022
ISSN:	2045-2322
Megjegyzések:	Altered periaqueductal gray matter (PAG) functional connectivity contributes to brain hyperexcitability in migraine. Although tryptophan modulates neurotransmission in PAG projections through its metabolic pathways, the effect of plasma tryptophan on PAG functional connectivity (PAG-FC) in migraine has not been investigated yet. In this study, using a matched case-control design PAG-FC was measured during a resting-state functional magnetic resonance imaging session in migraine without aura patients (n = 27) and healthy controls (n = 27), and its relationship with plasma tryptophan concentration (TRP) was assessed. In addition, correlations of PAG-FC with age at migraine onset, migraine frequency, trait-anxiety and depressive symptoms were tested and the effect of TRP on these correlations was explored. Our results demonstrated that migraineurs had higher TRP compared to controls. In addition, altered PAG-FC in regions responsible for fear-cascade and pain modulation correlated with TRP only in migraineurs. There was no significant correlation in controls. It suggests increased sensitivity to TRP in migraine patients compared to controls. Trait-anxiety and depressive symptoms correlated with PAG-FC in migraine patients, and these correlations were modulated by TRP in regions responsible for emotional aspects of pain processing, but TRP did not interfere with processes that contribute to migraine attack generation or attack frequency.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk migrén funkcionális konnektivitás
Megjelenés:	Scientific Reports. - 12 : 1 (2022), p. 1-12. -
További szerzők:	Dobos Dóra Aranyi Sándor Csaba (1988-) (programtervező informatikus) Galambos Attila Baksa Dániel Kocsel Natália Szabó Edina Pap Dorottya Virág Dávid Ludányi Krisztina (1976-) (gyógyszerész) Kökönyei Gyöngyi Emri Miklós (1962-) (fizikus) Bagdy György Juhász Gabriella
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