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001-es BibID:	BIBFORM100130
035-os BibID:	(WoS)000749463200001 (Scopus)85124021779
Első szerző:	Ratku Balázs (mentőtiszt)
Cím:	Effects of adult growth hormone deficiency and replacement therapy on the cardiometabolic risk profile / Balázs Ratku, Veronika Sebestyén, Annamária Erdei, Endre V. Nagy, Zoltán Szabó, Sándor Somodi
Dátum:	2022
ISSN:	1386-341X 1573-7403
Megjegyzések:	Adult growth hormone deficiency (AGHD) is considered a rare endocrine disorder involving patients with childhood-onset and adult-onset growth hormone deficiency (AoGHD) and characterized by adverse cardiometabolic risk profile. Besides traditional cardiovascular risk factors, endothelial dysfunction, low-grade inflammation, impaired adipokine profile, oxidative stress and hypovitaminosis D may also contribute to the development of premature atherosclerosis and higher cardiovascular risk in patients with AGHD. Growth hormone replacement has been proved to exert beneficial effects on several cardiovascular risk factors, but it is also apparent that hormone substitution in itself does not eliminate all cardiometabolic abnormalities associated with the disease. Novel biomarkers and diagnostic techniques discussed in this review may help to evaluate individual cardiovascular risk and identify patients with adverse cardiometabolic risk profile. In the absence of disease-specific guidelines detailing how to assess the cardiovascular status of these patients, we generally recommend close follow-up of the cardiovascular status as well as low threshold for a more detailed evaluation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Growth hormone deficiency Cardiometabolic risk Growth hormone replacement therapy Premature atherosclerosis
Megjelenés:	Pituitary. - 25 : 2 (2022), p. 211-228. -
További szerzők:	Borbásné Sebestyén Veronika (1990-) (biofizikus) Erdei Annamária (1976-) (belgyógyász) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Somodi Sándor (1977-) (belgyógyász)
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