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001-es BibID:	BIBFORM100136
Első szerző:	Csikós Anett (biomérnök, biológia-földrajz tanár)
Cím:	Polymorphisms identification of SLC30A (ZnTs) and SLC39A (ZIPs) Family genes in Hungary / Csikós Anett, Miklós Ida, Takács Péter
Dátum:	2018
Megjegyzések:	Zinc is the second most common trace element and catalytic cofactor in the human body. Zinc plays an important role in wound healing, biosynthesis and homeostasis of various connective tissues. A large number of proteins are known to regulate cellular Zn homeostasis and the most significant proteins belong to two protein families of Zn transporters. The solute carrier family 30 (SLC30A, also called ZnTs) and solute carrier family 39 (SLC39A, also called ZIPs) regulate Zn influx and efflux in the cells as well as intracellular compartments. Over the past few years, new knowledge accumulated in the international literature concerning Zn transporters. Fourteen ZIP and 10 ZnT proteins have been identified. The Hungarian population has not been investigated so far. Our research aims to eliminate this shortage. The present study was designed to test single nucleotide polymorphisms (SNPs) of the SLC30A and SLC39A genes. Samples of human blood were collected from 32 Hungarian women before their surgery for benign gynecological reasons. 24 markers were designed for the genetic variability of Hungarian isolates. Zinc transport loci could be amplified successfully in all patient samples included in the analysis. Thus more, than seven hundred samples will be applied in this work. Our results suggest that the 24 primers tested were found to be appropriate tools to detect the genetic variability of zinc transporters in the human blood samples. These primers will be applied in further studies to reveal the structure of Zinc transporters of the Hungarian populations.
Tárgyszavak:	Természettudományok Biológiai tudományok előadáskivonat könyvrészlet
Megjelenés:	A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium : Absztraktfüzet. - p. 10-11.
További szerzők:	Miklós Ida (1962-) (biológus) Takács Péter (1968-) (szülész-nőgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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