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001-es BibID:	BIBFORM101152
Első szerző:	Ni, Dong-Qi
Cím:	Titanium dioxide nanoparticles perturb the blood-testis barrier via disruption of actin-based cell adhesive function / Dong-Qi Ni, Dan-Dan Ma, Shuang-Li Hao, Wan-Xi Yang, Tamas Kovacs, Fu-Qing Tan
Dátum:	2021
ISSN:	1945-4589
Megjegyzések:	As one of the most commonly used nanoparticles, titanium dioxide nanoparticles (TiO2-NPs) are widely used as coating reagents in cosmetics, medicine and other industries. The increasing risk of exposure to TiO2-NPs raises concerns about their safety. In this study, we investigated the mechanism by which TiO2-NPs cross the bloodtestis barrier (BTB). TM-4 cells were selected as an in vitro Sertoli cell model of BTB. Cell viability, cell morphological changes, apoptosis, oxidative damage, and the expression levels of actin regulatory and tight junction (TJ) proteins were assessed in TM-4 cells treated with 3-nm and 24-nm TiO2-NPs. Cells treated with 3- nm TiO2-NPs exhibited increased cytotoxicity and decreased Annexin II expression, whereas cells treated with 24-nm TiO2-NPs exhibited increased Arp 3 and c-Src expression. Both TiO2-NPs induced significant oxidative stress, decreased the expression of TJ proteins (occludin, ZO-1 and claudin 5), damaged the TJ structure, and exhibited enlarged gaps between TM-4 cells. Our results indicated that both TiO2-NPs crossed the BTB by disrupting actin-based adhesive junctions of TM-4 cells; however, apoptosis was not observed. Our results provide new insights into how TiO2-NPs cross the BTB.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk TiO2-NPs blood-testis barrier TM-4 cell tight junction actin
Megjelenés:	Aging. - 13 : 23 (2021), p. 25440-25452. -
További szerzők:	Ma, Dan-Dan Hao, Shuang-Li Yang, Wan-Xi Kovács Tamás (1959-) (szülész-nőgyógyász, humángenetikus) Tan, Fu-Qing
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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