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001-es BibID:	BIBFORM102081
035-os BibID:	(cikkazonosító)3006 (WoS)000809980800001 (Scopus)85130822695
Első szerző:	Kövér Ágnes (szociológus)
Cím:	A Comprehensive Investigation into the Distribution of Circulating B Cell Subsets in the Third Trimester of Pregnancy / Ágnes Kövér, Rudolf Lampé, Krisztina Szabó, Tünde Tarr, Gábor Papp
Dátum:	2022
ISSN:	2077-0383
Megjegyzések:	Maternal B cells play a crucial role in the development and maintenance of pregnancy, due to their humoral activities and regulatory functions. In the study, we investigated the alterations in the distributions of naïve and memory B cell subsets, as well as regulatory B (Breg) cells, in the third trimester of pregnancy. Peripheral blood from 14 healthy pregnant women in the third trimester and 7 healthy non-pregnant women was collected and examined for the frequencies of B cell subsets, including IgD+CD27? naïve, IgD+CD27+ un-switched memory, IgD?CD27+ switched memory, CD38intCD24int mature?naïve, CD38?CD24hi primarily memory and CD38hiCD24hi transitional B cells by flow cytometry. Breg cell subsets were also characterized based on the expression of CD5, CD1d and IL-10. In pregnant women, the proportions of un-switched memory and transitional B cells were significantly decreased. Additionally, the frequencies of both CD5+CD1d+ Breg and IL-10-producing B10 cells were decreased in pregnancy. Changes in the distribution of transitional B cells as well as Breg cells may be crucial contributors for the development of altered maternal immune responses and tolerance needed for the maintenance of normal pregnancy in the third trimester.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Clinical Medicine. - 11 : 11 (2022), p. 1-11. -
További szerzők:	Lampé Rudolf (1983-) (szülész-nőgyógyász) Szabó Krisztina (1987-) (Molekuláris biológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Papp Gábor (1984-) (belgyógyász)
Pályázati támogatás:	K 124177 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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