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001-es BibID:	BIBFORM102964
035-os BibID:	(Wos)000461868900028 (Scopus)85061908762
Első szerző:	Ferrauto, Giuseppe
Cím:	Modifying LnHPDO3A Chelates for Improved and CEST MRI Applications / Ferrauto Giuseppe, Delli Castelli Daniela, Leone Loredana, Botta Mauro, Aime Silvio, Baranyai Zsolt, Tei Lorenzo
Dátum:	2019
ISSN:	0947-6539 1521-3765
Megjegyzések:	The new ligand HPDO3MA [(R,R,R,R)-10-(2-hydroxypropyl)-alpha,alpha,alpha-trimethyl-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid] was designed to combine and optimize the chemical properties of the macrocyclic ligands HPDO3A and DOTMA. The presence of the methyl groups on the acetic pendant arms of HPDO3A is expected to rigidify the structure of the ligand and favor an increase of the kinetic inertness of the Ln complexes. H-1 NMR spectra of Eu(HPDO3MA) displayed the presence of two pairs of diastereoisomers: SAP (square antiprismatic) and TSAP (twisted square antiprismatic) isomers (56 and 44 %, respectively). In addition, H-1 and O-17 relaxometric NMR studies of Gd(HPDO3MA) showed approximately a 10 % increase in relaxivity and a faster water exchange rate with respect to Gd(HPDO3A). Moreover, a detailed chemical exchange saturation transfer (CEST) characterization of Yb(HPDO3MA) displayed a sensitivity about two times larger than that of Yb(HPDO3A) both in phantom and in cell labeling experiments. Finally, the kinetic inertness of Yb(HPDO3MA) was measured to be twice as high as that of Yb(HPDO3A), with a dissociation half-life at physiological pH of about 2500 years.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Chemistry-A European Journal. - 25 : 16 (2019), p. 4184-4193. -
További szerzők:	Castelli, Daniela Delli Leone, Loredana Botta, Mauro Aime, Silvio Tei, Lorenzo Baranyai Zsolt (1977-) (vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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