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001-es BibID:	BIBFORM103106
035-os BibID:	(WOS)000228340800003 (Scopus)19544370693
Első szerző:	Röszer Tamás (orvos, biológus)
Cím:	Seasonal periodicity of enteric nitric oxide synthesis and its regulation in the snail, Helix lucorum / Tamás Röszer, Éva Kiss-Tóth, A. József Szentmiklósi, Gáspár Bánfalvi
Dátum:	2005
ISSN:	1077-8306
Megjegyzések:	The snail Helix lucorum has been used as a model to study the adaptation of a nitric oxide (NO)-forming enteric neural network to the long-term resting period of summer estivation or winter hibernation. Quantification of the NO-derived nitrite established that NO formation is confined to the nitric oxide synthase (NOS)-containing myenteric network of the mid-intestine. In active snails but not in resting snails, NO production could be enhanced by the NOS substrate l-arginine (l-ARG, 1?mM). We followed the enteric NO synthesis in a snail population kept at natural conditions for 1 year. Our findings indicate that NO synthesis was depressed in July during entry to the estivation, had a peak in autumn before hibernation, and finally was reduced during hibernation. Monoamines (histamine, serotonin, and adrenalin) could inhibit the NO liberation in active snails. Cofactors of NOS (?-NADPH, ?-NAD, FAD, FMN, Ca2+, TH4) did not alter the low nitrite production in hibernating snails. We conclude that enteric NO synthesis in H. lucorum has a regular seasonal periodicity following the annual physiological cycles of terrestrial snails. During estivation or hibernation, NOS activity is blocked. Monoamines, the levels of which are elevated during hibernation, can trigger decreased NOS activity. The reduced activity of NOS cannot be restored by the administration of NOS cofactors; therefore, their absence cannot be the cause of the temporarily blocked L-ARG/NO conversion ability of NOS.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk NADPH diaphorase nitric oxide synthase enteric nervous system Helix lucorum
Megjelenés:	Invertebrate Biology. - 124 : 1 (2005), p. 18-24. -
További szerzők:	Kiss-Tóth Éva (1983-) (biológus) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Bánfalvi Gáspár (1943-) (sejtbiológus, gyógyszerész)
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