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001-es BibID:	BIBFORM103107
035-os BibID:	(Wos)000413395700029 (Scopus)85028650246
Első szerző:	Waqas, Syed F. Hassnain
Cím:	Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse / Syed F. Hassnain Waqas, Anna Noble, Anh C. Hoang, Grace Ampem, Manuela Popp, Sarah Strauss, Matthew Guille, Tamás Röszer
Dátum:	2017
ISSN:	0741-5400
Megjegyzések:	ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident M?s are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk fat body yolk sac M phi s CX(3)CR1 neuropeptide FF
Megjelenés:	Journal Of Leukocyte Biology. - 102 : 3 (2017), p. 845-855. -
További szerzők:	Noble, Anna Hoang, Anh Cuong Ampem, Grace Popp, Manuela Strauss, Sarah Guille, Matthew Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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