Találati lista | Tudóstér

001-es BibID:	BIBFORM103130
035-os BibID:	(Wos)000348962700035 (Scopus)84922169574
Első szerző:	Menendez-Gutierrez, Maria Piedad
Cím:	Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling / María P. Menéndez-Gutiérrez, Tamás Röszer, Lucia Fuentes, Vanessa Núnez, Amelia Escolano, Juan Miguel Redondo, Nora De Clerk, Daniel Metzger, Annabel F. Valledor, Mercedes Ricote
Dátum:	2015
ISSN:	0021-9738
Megjegyzések:	Osteoclasts are bone-resorbing cells that are important for maintenance of bone remodeling and mineral homeostasis. Regulation of osteoclast differentiation and activity is important for the pathogenesis and treatment of diseases associated with bone loss. Here, we demonstrate that retinoid X receptors (RXRs) are key elements of the transcriptional program of differentiating osteoclasts. Loss of RXR function in hematopoietic cells resulted in formation of giant, nonresorbing osteoclasts and increased bone mass in male mice and protected female mice from bone loss following ovariectomy, which induces osteoporosis in WT females. The increase in bone mass associated with RXR deficiency was due to lack of expression of the RXR-dependent transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (MAFB) in osteoclast progenitors. Evaluation of osteoclast progenitor cells revealed that RXR homodimers directly target and bind to the Mafb promoter, and this interaction is required for proper osteoclast proliferation, differentiation, and activity. Pharmacological activation of RXRs inhibited osteoclast differentiation due to the formation of RXR/liver X receptor (LXR) heterodimers, which induced expression of sterol regulatory element binding protein-1c (SREBP-1c), resulting in indirect MAFB upregulation. Our study reveals that RXR signaling mediates bone homeostasis and suggests that RXRs have potential as targets for the treatment of bone pathologies such as osteoporosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Clinical Investigation. - 125 : 2 (2015), p.809-823. -
További szerzők:	Röszer Tamás (1979-) (orvos, biológus) Fuentes, Lucía Núnez, Vanessa Escolano, Amelia Redondo, Juan Miguel De Clerk, Nora Metzger, Daniel Valledor, Annabel F. Ricote, Mercedes
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: