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001-es BibID:	BIBFORM103350
035-os BibID:	(Scopus)76449094520 (WOS)000272247100007 (cikkazonosító)19388
Első szerző:	Kissling, Esther
Cím:	"I-MOVE" towards monitoring seasonal and pandemic influenza vaccine effectiveness : lessons learnt from a pilot multi-centric case-control study in Europe, 2008-9 / E. Kissling, M. Valenciano, J. M. Falcão, A. Larrauri, K. Widgren, D. Pitigoi, B. Oroszi, B. Nunes, C. Savulescu, A. Mazick, E. Lupulescu, B. Ciancio, A. Moren
Dátum:	2009
ISSN:	1025-496X 1560-7917
Megjegyzések:	Within I-MOVE (European programme to monitor seasonal and pandemic influenza vaccine effectiveness (IVE)) five countries conducted IVE pilot case-control studies in 2008-9. One hundred and sixty sentinel general practitioners (GP) swabbed all elderly consulting for influenza-like illness (ILI). Influenza confirmed cases were compared to influenza negative controls. We conducted a pooled analysis to obtain a summary IVE in the age group of ?65 years. We measured IVE in each study and assessed heterogeneity between studies qualitatively and using the I2 index. We used a one-stage pooled model with study as a fixed effect. We adjusted estimates for age-group, sex, chronic diseases, smoking, functional status, previous influenza vaccinations and previous hospitalisations. The pooled analysis included 138 cases and 189 test-negative controls. There was no statistical heterogeneity (I2=0) between studies but ILI case definition, previous hospitalisations and functional status were slightly different. The adjusted IVE was 59.1% (95% CI: 15.3-80.3%). IVE was 65.4% (95% CI: 15.6-85.8%) in the 65-74, 59.6% (95% CI: -72.6 -90.6%) in the age group of ?75 and 56.4% (95% CI: -0.2-81.3%) for A(H3). Pooled analysis is feasible among European studies. The variables definitions need further standardisation. Larger sample sizes are needed to achieve greater precision for subgroup analysis. For 2009-10, I-MOVE will extend the study to obtain early IVE estimates in groups targeted for pandemic H1N1 influenza vaccination.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Eurosurveillance. - 14 : 44 (2009), p. 29-36. -
További szerzők:	Valenciano, Marta Falcão, J. M. Larrauri, Amparo Widgren, K. Pitigoi, Daniela Oroszi Beatrix (1970-) (orvos, epidemiológus) Nunes, Baltazar Savulescu, Camelia Mazick, A. Lupulescu, Emilia Ciancio, Bruno Moren, Alain
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