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001-es BibID:	BIBFORM103355
035-os BibID:	(WOS)000355705700014 (Scopus)84929289547
Első szerző:	Valenciano, Marta
Cím:	The European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2) / Marta Valenciano, Esther Kissling, Annicka Reuss, Silvia Jiménez-Jorge, Judit K. Horváth, Joan M. O. Donnell, Daniela Pitigoi, Ausenda Machado, Francisco Pozo, I-MOVE Multicentre Case Control Study Team
Dátum:	2015
ISSN:	0264-410X
Megjegyzések:	Background In the first five I-MOVE (Influenza Monitoring Vaccine Effectiveness in Europe) influenza seasons vaccine effectiveness (VE) results were relatively homogenous among participating study sites. In 2013?2014, we undertook a multicentre case-control study based on sentinel practitioner surveillance networks in six European Union (EU) countries to measure 2013?2014 influenza VE against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. Influenza A(H3N2) and A(H1N1)pdm09 viruses co-circulated during the season. Methods Practitioners systematically selected ILI patients to swab within eight days of symptom onset. We compared cases (ILI positive to influenza A(H3N2) or A(H1N1)pdm09) to influenza negative patients. We calculated VE for the two influenza A subtypes and adjusted for potential confounders. We calculated heterogeneity between sites using the I2 index and Cochrane's Q test. If the I2 was <50%, we estimated pooled VE as (1 minus the OR) ? 100 using a one-stage model with study site as a fixed effect. If the I2 was >49% we used a two-stage random effects model. Results We included in the A(H1N1)pdm09 analysis 531 cases and 1712 controls and in the A(H3N2) analysis 623 cases and 1920 controls. For A(H1N1)pdm09, the Q test (p = 0.695) and the I2 index (0%) suggested no heterogeneity of adjusted VE between study sites. Using a one-stage model, the overall pooled adjusted VE against influenza A(H1N1)pdm2009 was 47.5% (95% CI: 16.4?67.0). For A(H3N2), the I2 was 51.5% (p = 0.067). Using a two-stage model for the pooled analysis, the adjusted VE against A(H3N2) was 29.7 (95% CI: ?34.4?63.2). Conclusions The results suggest a moderate 2013?2014 influenza VE against A(H1N1)pdm09 and a low VE against A(H3N2). The A(H3N2) estimates were heterogeneous among study sites. Larger sample sizes by study site are needed to prevent statistical heterogeneity, decrease variability and allow for two-stage pooled VE for all subgroup analyses.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Influenza vaccine Influenza vaccine effectiveness Multicentre study Test-negative design Vaccine effectiveness
Megjelenés:	Vaccine. - 33 : 24 (2015), p. 2813-2822. -
További szerzők:	Kissling, Esther Reuss, Annicka Jiménez-Jorge, Silvia Horváth Judit Krisztina Donnell, Joan M. O. Pitigoi, Daniela Machado, Ausenda Pozo, Francisco Oroszi Beatrix (1970-) (orvos, epidemiológus) I-MOVE Multicentre Case Control Study Team
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