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001-es BibID:	BIBFORM103454
035-os BibID:	(cikkazonosító)5499 (WOS)000851911100001 (Scopus)85137571558
Első szerző:	Gavra, Diana Ioana
Cím:	In Vitro and Human Pilot Studies of Different Topical Formulations Containing Rosa Species for the Treatment of Psoriasis / Diana Ioana Gavra, Laura Endres, Ágota Pető, Liza Józsa, Pálma Fehér, Zoltán Ujhelyi, Annamária Pallag, Eleonóra Marian, Laura Gratiela Vicas, Timea Claudia Ghitea, Mariana Muresan, Ildikó Bácskay, Tünde Jurca
Dátum:	2022
ISSN:	1420-3049
Megjegyzések:	The aim of this study was to evaluate the phytochemical profile and antioxidant properties of the extracts from three Rosa species (R. canina, R. damascena, R. cairo), to develop and investigate topical formulations with lyophilized forms of extracts for the treatment of psoriasis. Phytochemical screening and in vitro total antioxidant capacity (DPPH, FRAP, CUPRAC, SOD) of studied samples were examined and compared. Lyophilized extracts of roses were dissolved in Transcutol HP and different formulations of creams were prepared. Franz diffusion method was used to evaluate the drug release and biocompatibility was tested on HaCaT cells. Rosa damascene had the best results regarding all the analyses that were conducted. After the evaluation of topical products, the formulation with Rosa damascena extract in a self-emulsifying drug delivery system was tested on a human clinical study that involved 20 patients. At the end of the clinical study an improvement in the quality of life of the patients was observed and erythema, induration and scaling were reduced. The present study indicates that our examined extracts exhibited great phenolic content, antioxidant capacity and safety profile of topical formulation and therefore can be used as a reliable source of natural antioxidants and may be used as a complementary treatment to improve the quality life of patients with psoriasis or may be tested on another diseases.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk phytochemical profile antioxidant capacity bioactive compounds topical formulation human clinical study biocompatibility
Megjelenés:	Molecules. - 27 : 17 (2022), p. 1-24. -
További szerzők:	Endres Laura Pető Ágota (1994-) (gyógyszerész) Józsa Liza (1994-) (gyógyszerész) Fehér Pálma (1976-) (gyógyszerész) Ujhelyi Zoltán (1984-) (gyógyszerész) Pallag Annamária Marian, Eleonora Vicaș, Laura Grațiela Ghitea, Timea Claudia Muresan, Mariana Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Jurca Tünde
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