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001-es BibID:	BIBFORM103786
Első szerző:	Tóth E. Béla (orvos)
Cím:	Klinikai vizsgálatok értékelése az alkalmazott d-vitamin terápia az elesési- és a csonttörési kockázat tekintetében = Risk of falls and fractures associated with vitamin D therapies in scope of clinical rials / Tóth E. Béla, Mirani Sara, Horváth László, Tóth Áron, Vecsernyés Miklós
Dátum:	2020
ISSN:	0001-6659
Megjegyzések:	Background Scientific and clinical evidences documented that vitamin D is essential to maintain calcium absorption and consequently the normal funtion of the musculoskeletal system in human. The deficiency is rather endemic due to significant Vitamin D deficiency detected among most of population. Clinical trial data over the past decades clearly support the skeletal benefits of vitamin D supplementation in patients with circulating 25OHD levels of less than 30 nmol/L. The role of vitammin D supplementation has been establashed for the indication also in prevention to minimize the risk of falls and fractures in general. However, the use of bolus or high-dose vitamin D supplementation in clinical trials among elderly people shown unexpeced adverse drug reactions and the need for further surveillance in dosing specifications of vitamin D therapies. Aims An overall goal is to establish the safety specificiaction of vitamin D supplementation for prevention and also in various medical conditions in order to minimise the risk of falls and fractures in elderly population. Additionally, to identify the risks associated with the most relevant life-style factors and nutritional conditions that may interfere with the success of vitamin D supplementation applied for prevenetion in general. Methods The results of clinical trials based on observational studies at clinical facilities and supported by survey in general public focused on alimentary, solar exposition, the use of dietary- and food supplementation but also assessed the edherence to given medications and other life-style factors. Results VItamin D supplementation is indicated below 75 nmol/L, which is almost 90% of population among elderly and approx. 65-70% in general for the mass of population. The risk of fractures are significantly higher among patients with low 25OHD levels (OR 2.83; CL 1.51-5.31, p=0.007). But over 25% of population is not adherent to prescribed OP therapies. Alimenentary and life-style conditions are both needed optimal skeletal health: two-thirds of the subjects are underestimated their daily calcium intake, although only less then 30% of them are aware of the importance of calcium intake. Moreover, the physical activity level is being adequate in case of 28% even among the younger population. Conclusion The option of loading plus maintenance dose schedule proven to be efficient in cases of significant Vitamin D deficiency, however with proper nutritional and life-style conditions only in reduction of risk of falls and fractures.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok poszter folyóiratcikk
Megjelenés:	Acta Pharmaceutica Hungarica. - 90 : 2-3 (2020), p. 187. -
További szerzők:	Mirani, Sara (1978-) (Phd hallgató) Horváth László (1973-) (gyógyszerész) Tóth Áron (1987-) (mérnök informatikus) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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