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001-es BibID:	BIBFORM103943
035-os BibID:	(cikkazonosító)0300060520920439 (WOS)000541846600001 (Scopus)85086327021
Első szerző:	Maros-Szabó Zsuzsanna
Cím:	Increased symmetric dimethylarginine, but not asymmetric dimethylarginine, concentrations are associated with transient myocardial ischemia and predict outcome / Zsuzsanna Szabo, Eva Bartha, Lajos Nagy, Tihamer Molnar
Dátum:	2020
ISSN:	0300-0605 1473-2300
Megjegyzések:	Objective Asymmetric and symmetric dimethylarginines (ADMA and SDMA) are endothelial dysfunction markers. ADMA inhibits synthesis of nitric oxide. We aimed to analyze both markers in patients with coronary artery disease (CAD) who were referred for stress/rest myocardial perfusion scintigraphy (MPS). Methods All patients underwent a 2-day dipyridamole (DP) stress/rest protocol. Thereafter, patients with transient myocardial perfusion abnormality were followed up and their coronary blood flow was quantitatively assessed. Venous blood was taken before and after DP stress to measure markers. Results Baseline ADMA and SDMA concentrations were significantly higher in patients with CAD compared with healthy subjects. Pre- and post-stress SDMA concentrations were significantly higher in patients with transient myocardial perfusion abnormality compared with those with negative MPS results. However, ADMA and L-arginine concentrations were not significantly different between the two groups. None of the markers were significantly different between patients with angiographically proven low coronary flow and those with normal coronary flow. Pre-stress SDMA concentrations were an independent predictor of cardiovascular mortality during a 8-year follow-up. Conclusions Elevated serum SDMA concentrations may be helpful for selecting high-risk patients with CAD if there is any doubt in interpreting MPS. SDMA concentrations may also predict cardiovascular outcome.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Dipyridamole coronary artery disease asymmetric dimethylarginine myocardial perfusion scin-tigraphy L-arginine cardiovascular mortality
Megjelenés:	Journal of International Medical Research. - 48 : 6 (2020), p. 1-9. -
További szerzők:	Bartha Éva (radiológus) Nagy Lajos (1979-) (vegyész) Molnár Tihamér (1992-) (általános orvos)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00009 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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