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001-es BibID:	BIBFORM104028
035-os BibID:	(cikkazonosító)513 (WOS)000515503100020 (Scopus)85079629767
Első szerző:	Silva, Francisco
Cím:	Dual imaging gold nanoplatforms for targeted radiotheranostics / Francisco Silva, António Paulo, Agnès Pallier, Sandra Même, Éva Tóth, Lurdes Gano, Fernanda Marques, Carlos F.G.C. Geraldes, M. Margarida C.A Castro, Ana M. Cardoso, Amália S. Jurado, Pilar López-Larrubia, Sara Lacerda, Maria Paula Cabral Campello
Dátum:	2020
ISSN:	1996-1944
Megjegyzések:	Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and Ga-67(3+) for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNPs carry a bombesin analogue with affinity towards the gastrin releasing peptide receptor (GRPr), overexpressed in a variety of human cancer cells, namely PC3 prostate cancer cells. The potential of these multimodal imaging nanoconstructs was thoroughly investigated by the assessment of their magnetic properties, in vitro cellular uptake, biodistribution, and radiosensitisation assays. The relaxometric properties predict a potential T-1- and T-2- MRI application. The promising in vitro cellular uptake of Ga-67/Gd-based bombesin containing particles was confirmed through biodistribution studies in tumor bearing mice, indicating their integrity and ability to target the GRPr. Radiosensitization studies revealed the therapeutic potential of the nanoparticles. Moreover, the DOTA chelating unit moiety versatility gives a high theranostic potential through the coordination of other therapeutically interesting radiometals. Altogether, our nanoparticles are interesting nanomaterial for theranostic application and as bimodal T-1- and T-2- MRI / SPECT imaging probes.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk gold nanoparticles multimodality MRI SPECT bombesin PC3 tumor radiosensitization
Megjelenés:	Materials. - 13 : 3 (2020), p. 1-17. -
További szerzők:	Paulo, António Pallier, Agnès Même, Sandra Tóth Éva (1967-) (koordinációs kémia) Gano, Lurdes Marques, Fernanda Geraldes, Carlos Frederico de Gusmão Campos Castro, M. M. C. A. Cardoso, Ana M. Jurado, Amália S. López-Larrubia, Pilar Lacerda, Sara Cabral Campello, Maria Paula
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