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001-es BibID:	BIBFORM104052
035-os BibID:	(WoS)000495127500005 (Scopus)85074074012
Első szerző:	Kovács Ervin
Cím:	Synthesis and supramolecular assembly of fluorinated biogenic amine recognition host polymers / Ervin Kovács, János Deme, Gábor Turczel, Tibor Nagy, Vajk Farkas, László Trif, Sándor Kéki, Péter Huszthy, Robert Tuba
Dátum:	2019
ISSN:	1759-9954 1759-9962
Megjegyzések:	Copolymers containing hydroxyl (i.e. vinyl alcohol, VA) or fluorine functionalities are synthetic macromolecules having prominent biomedical applications. The concentration of hydroxyl groups along the polymer chain controls the polymer polarity. Moreover, the introduction of perfluorinated organic moieties via the OH functionalities may lead to macromolecules having potential magnetic resonance imaging (MRI) active properties. The ring-opening metathesis polymerization (ROMP) reaction using well-defined ruthenium-catalyzed systems is one of the most promising synthetic tools to fabricate such polymers. Co-polymerization of norbornene grafted pyridino-18-crown-6 ether (7) with fluorine-functionalized norbornenes (10 and 11) results in polymers bearing host molecular moieties. It has been demonstrated that the complexation of these host copolymers with biogenic amines including dopamine hydrochloride (12) and l-alanyl-l-lysine dipeptide hydrochloride (13) is straightforward. Based on the H-1 NMR investigation of the 7 and 12 complexation, an equilibrium constant of logK = 4.3 +/- 0.6 could be calculated. The in situ(1)H NMR investigations have revealed that the complex formation of 13 with monomer 7 and perfluorinated copolymer cp-7-10 takes place via both the lysine -NH3+ and the alanine -NH3+ moieties. However, in the case of homopolymer poly-7, the lysine-NH3+ group coordination was observed exclusively. According to theoretical calculations, molecular switching of the crown ether structure of both the 7 monomer and its cp-7-10 copolymer were observed from 90 degrees bent to planar structure upon -NH3+ ion coordination.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Polymer Chemistry. - 10 : 41 (2019), p. 5626-5634. -
További szerzők:	Deme János Turczel Gábor Nagy Tibor (orvos) Farkas Vajk Trif László Kéki Sándor (1964-) (polimer kémikus) Huszthy Péter Tuba Róbert
Pályázati támogatás:	NVKP-16- 1-2016-0007 Egyéb GINOP-2.3.2-15-2016-00017 GINOP PD 120776 Egyéb K128473 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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