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001-es BibID:	BIBFORM104058
035-os BibID:	(cikkazonosító)3707 (WOS)000577843800001 (Scopus)85089819884
Első szerző:	Manček-Keber, Mateja
Cím:	Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages / Mateja Manček-Keber, Rosana Ribić, Fernando Chain, Davy Sinnaeve, José C. Martins, Roman Jerala, Srďanka Tomić, Krisztina Fehér
Dátum:	2020
ISSN:	1420-3049
Megjegyzések:	We report the enhancement of the lipopolysaccharide-induced immune response by adamantane containing peptidoglycan fragments in vitro. The immune stimulation was detected by Il-6 (interleukine 6) and RANTES (regulated on activation, normal T cell expressed and secreted) chemokine expression using cell assays on immortalized mouse bone-marrow derived macrophages. The most active compound was a alpha-D-mannosyl derivative of an adamantylated tripeptide with L-chirality at the adamantyl group attachment, whereby the mannose moiety assumed to target mannose receptors expressed on macrophage cell surfaces. The immune co-stimulatory effect was also influenced by the configuration of the adamantyl center, revealing the importance of specific molecular recognition event taking place with its receptor. The immunostimulating activities of these compounds were further enhanced upon their incorporation into lipid bilayers, which is likely related to the presence of the adamantyl group that helps anchor the peptidoglycan fragment into lipid nanoparticles. We concluded that the proposed adamantane containing peptidoglycan fragments act as co-stimulatory agents and are also suitable for the preparation of lipid nanoparticle-based delivery of peptidoglycan fragments.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk peptidoglycan immunostimulation lipid incapsulation adamantane mannose
Megjelenés:	Molecules. - 25 : 16 (2020), p. 1-10. -
További szerzők:	Ribić, Rosana Chain, Fernando Sinnaeve, Davy Martins, José C. Jerala, Roman Tomić, Srďanka Fehér Krisztina (1974-) (vegyész)
Pályázati támogatás:	BO/004333/18/7 Egyéb ÚNKP-19-4 Egyéb NN-128368) OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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