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001-es BibID:	BIBFORM104104
035-os BibID:	(Scopus)84929135575
Első szerző:	Röszer Tamás (orvos, biológus)
Cím:	Nitric oxide signaling and nitrosative stress in the musculoskeletal system / Röszer T.
Dátum:	2014
Megjegyzések:	Nitric oxide (NO) is a multifaceted signaling molecule in the musculoskeletal system. In bone, NO can act as a signal molecule and has anabolic effects by supporting bone formation and repressing bone resorption. In skeletal muscles, NO has a major role in the self-regulation of arteriolar blood flow and is also involved in the control of Ca2+ dynamics, glucose metabolism, mitochondrial oxidative phosphorylation, immune response, and muscle and tendon regeneration. Altered NO production in the skeletal system is associated with pathologies of high morbidity, such as osteoporosis, osteoarthritis, and rheumatoid arthritis and with non-curable progressive dystrophies in muscles. NO thus has medical importance; however, there are still roadblocks that do not allow effective modulation of NO homeostasis in diseases of the musculoskeletal system. This chapter provides an overview of current knowledge of the roles and possible pharmacological targeting of NO and NO derived radicals in the musculoskeletal system.
ISBN:	978-3-642-30017-2
Tárgyszavak:	Orvostudományok Elméleti orvostudományok könyvfejezet könyvrészlet Bone Inflammation Joint Muscle Nitric oxide Peroxynitrite Tendon
Megjelenés:	Systems Biology of Free Radicals and Antioxidants / ed. Ismail Laher. - p. 2895-2926. -
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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