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001-es BibID:	BIBFORM105071
Első szerző:	Pikó Péter (biológus)
Cím:	Generalisability of effect size estimates for SNPs related to HDL-C obtained on European populations / P. Pikó, S. Fiatal, Z. Kósa, J. Sándor, R. Ádány
Dátum:	2017
ISSN:	1101-1262
Megjegyzések:	Background Large scale association studies that mainly involve European populations identified many genetic loci related to high density lipoprotein cholesterol (HDL-C) levels, the most important indicator of the risk for cardiovascular diseases. Data on non-European populations are just emerging consequently, the generalisability of the association results to non-European populations are pending. We addressed the question whether the individual effect of established HDL-C level related genetic loci are applicable to the Roma population considered to have a South Asian origin. Methods We examined association of 21 SNPs (in genes LIPC(G), CETP, GALNT2, HMGCP, ABCA1, KCTD10 and WWOX) with HDL-C levels by linear regression models using age and sex as covariates. Single SNP associations (direction and magnitude of the effect on HDL-C) were estimated. Analyses were conducted in adults of the Hungarian General (N = 1542) and Hungarian Roma (N = 646) populations. Results The SNPs had small individual effects on HDL-C levels. The beta-coefficients for the general population were found to be identical both in direction and magnitude, indicating that the effect is concordant with large scale studies of European populations obtained previously. Among Roma in case of two SNPs the effect direction, while in case of one SNP the effect size differed in comparison with the general population. Significant associations between SNPs and HDL-C levels were more likely to be seen among general subjects compared to Roma (Roma: 5 SNPs; General: 10 SNPs). The CETP gene variants rs1532624, rs708272 and rs7499892; and the KCTD10 gene rs2338104 variant showed significant associa tions with HDL-C levels consistently in study groups (p < 0.05). Conclusions The patterns of influence of SNPs on HDL-C were consistent across ethnic groups, in large extent, but alteration observed even in effect direction in case of few SNPs indicate that data obtained on European populations can be applied with caution
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 27 : suppl3 (2017), p. 466. -
További szerzők:	Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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