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001-es BibID:	BIBFORM105441
Első szerző:	Nádasi Edit
Cím:	HER2, P53, FAS, FASL, COX2, PGE2S, EGFR expression in breast cancer and in normal peritumoral breast tissue : potential novel risk biomarkers / Edit Nádasi, János Sándor, Marcella Mottolese, AnnaMaria Cianciulli, Pier Giorgio Natali, István Ember
Dátum:	2004
Megjegyzések:	We analyzed, by using specific antibodies, HER2, p53, Fas and Fas ligand (FasL), expression in 72 breast carcinomas, the corresponding autologous peritumoral tissues (PTT) sampled at 1, 2 and 3 cm from the tumor itself and in 44 benign mammary lesions. Ten breast carcinomas and their autologous 1-cm PTT samples were also analyzed by fluorescent in situ hybridization (FISH) to determine if HER2 gene amplification can be demonstrated in the background of cytoplasmic immunohistochemical HER2 staining. A further 186 stage I-II primary BC and 95 autologous lymph node metastases were analyzed immunohistochemically for cyclooxygenase-2 (COX2), hormone receptors, p53, HER2, Ki67, Fas, FasL and epidermal growth factor receptor (EGFR) expression, to determine their effects on the prognosis of breast cancer patients receiving chemotherapy. The results obtained suggest that HER2 gene amplification often underlies cytoplasmic HER2 staining when analyzed immunohistochemically. Furthermore, breast carcinomas and the closest adjacent uninvolved parenchyma shared an up-regulated FasL phenotype, which is lost in PTT farther from the tumor. Therefore, among the biological parameters investigated, HER2 and FasL expressions seem to represent biomarkers of breast tumorigenesis easily applicable to fine-needle aspirates and potentially useful to detect patients at high risk of breast carcinoma. Moreover, in high-risk breast cancer patients, the immunohistochemical evaluation of COX2, together with PGE2S, p53, Ki67, HER2, Fas and FasL, may be of clinical value in determining 5-year disease-free survival and overall survival for the patient.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk Breast cancer
Megjelenés:	Anticancer Research. - 24 : 5D Suppl (2004), p. 3574. -
További szerzők:	Sándor János (1966-) (orvos-epidemiológus) Mottolese, Marcella Cianciulli, AnnaMaria Natali, Pier Giorgio Ember István
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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