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001-es BibID:	BIBFORM105442
Első szerző:	Orsós Zsuzsa
Cím:	Allelic polymorphisms of metabolizing enzymes in a Hungarian roma population / Zsuzsa Orsós, Judit Béres, János Sándor, István Ember, István Kiss
Dátum:	2004
ISSN:	0250-7005 1791-7530
Megjegyzések:	The Roma population is the largest ethnic minority in Hungary. Their mortality structure differs from the national average. This is partly caused by life-style, environmental and social factors, but genetic factors may also be responsible. Concerning cancer morbidity and mortality, such genetic factors can be polymorphisms of certain metabolizing enzymes, which (based on literature data and on our previous studies) may have an influence on susceptibility to cancer. In the present study, we investigated the allelic polymorphisms of N-acetyltransferase 2 (NAT2), a glutathione-S-transferase M1 (GSTM1), glutathione-S transferase T1 (GSTT1) and cytochrome P450 1A1 (CYP 1A1) metabolizing enzymes in a large group of the Hungarian Romas. The allelic freqencies were compared to the data for the non Roma population. Sample collection was performed in the framework of Roma Project (195 blood samples), genotyping was made from peripheral leukocytes, with PCR based methods (NAT2: rapid and slow acetylators, GST M1 and T1: 0 and + genotypes, CYP 1A1: Ile/Val polymorphism). Our results demonstrated a difference between the allelic distributions of Roma and non Roma populations. Allelic frequencies of GSTM1 (OR: 2.08, 95% CI: 1.45-2.99) and NAT2 (OR: 1.42, 95% CI: 1.00-2.00) were significantly different, while in the case of GSTT1 and CYP 1A1, there was no statistically significant difference. Since both GSTM1 and NAT polymorphisms might have an influence on susceptibility to certain cancers (e.g. colorectal, bladder and lung cancer), the differences found in the allelic distributions may contribute to the mortality differences between the Hungarian Roma and non Roma populations. This hypothesis, however, must be confirmed, e.g. by studying allelic polymorphisms among cancer patients from the Roma population.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk ALLELIC POLYMORPHISMS
Megjelenés:	Anticancer Research. - 24 : 5D Suppl (2004), p. 3587. -
További szerzők:	Béres Judit Sándor János (1966-) (orvos-epidemiológus) Ember István Kiss István
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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