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001-es BibID:	BIBFORM105679
035-os BibID:	(scopus)85138128690 (wos)000852379900003 (cikkazonosító)219
Első szerző:	Péter Andrea (kardiológus)
Cím:	Subclinical systolic and diastolic myocardial dysfunction in polyphasic polymyositis/dermatomyositis : a 2-year longitudinal study / Péter Andrea, Balogh Ágnes, Csanádi Zoltán, Dankó Katalin, Griger Zoltan
Dátum:	2022
ISSN:	1478-6354 1478-6362
Megjegyzések:	Background Cardiac involvement in patients with idiopathic inflammatory myopathies (IIM) is associated with increased morbidity and mortality risk; however, little is known about the progression of cardiac dysfunction and long-term data are scarce. In the present work, we intended to prospectively study echocardiographic parameters in patients with IIM for 2 years. Methods Twenty-eight IIM patients (41.9?1.6 years) without cardiovascular symptoms were enrolled. Patients with monophasic/polyphasic disease patterns were studied separately and compared to age-matched healthy individuals. Conventional echocardiographic and tissue Doppler imaging (TDI) parameters of systolic [LV: ejection fraction (EF), mitral annulus systolic movement (MAPSE), lateral s·) and diastolic left (mitral inflow velocities, lateral anulus velocities: e·, a·, E/e·) and right ventricular function (fractional area change: FAC, tricuspid annulus plane systolic excursion: TAPSE) were measured at the time of the diagnosis and 2 years later. Results Subclinical LV systolic dysfunction is characterized by reduced lateral s· (10.4 vs. 6.4 cm/s, p<0.05), EF (62.6?0.6%, vs. 51.7?0.7%) and MAPSE (18.5?0.6 vs. 14.5?0.6 mm) could be observed in IIM patients with polyphasic disease course 2 years after diagnosis compared to controls. Furthermore, diastolic LV function showed a marked deterioration to grade I diastolic dysfunction at 2 years in the polyphasic group (lateral e·: 12.9 ?0.6, vs. 7.4?0.3 cm/s; lateral a·: 10.7?0.3, vs. 17.3?0.8 cm/s; p<0.05) supported by larger left atrium (32.1?0.6 vs. 37.8?0.6 mm; p<0.05]. TDI measurements confirmed subclinical RV systolic dysfunction in polyphasic patients 2 years after diagnosis (FAC: 45.6?1.8%, vs. 32.7?1.4%; TAPSE: 22.7?0.5, vs. 18.1?0.3 mm; p<0.05). Similar, but not significant tendencies could be detected in patients with monophasic disease patterns. Polyphasic patients showed significantly (p<0.05) worse results compared to monophasic patients regarding EF (51.7?0.7% vs. 58.1?0.6%), lateral s· (6.4?0.4 cm/sec vs. 8.6?0.4 cm/s,), left atrium (37.8?0.6 mm vs. 33.3?0.8 mm), FAC (32.7?1.4% vs. 41.0?1.6%) and TAPSE (18.1?0.3 mm vs. 21.3?0.7 mm). Conclusions Significant subclinical cardiac dysfunction could be detected in IIM patients with polyphasic disease course 2 years after diagnosis, which identifies them as a high-risk population. TDI is a useful method to detect echocardiographic abnormalities in IIM complementing conventional echocardiography and can recognize the high cardiac risk.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cardiac involvement Dermatomyositis Echocardiography Polymyositis Tissue Doppler imaging
Megjelenés:	Arthritis Research & Therapy. - 24 : 1 (2022), p. 1-11. -
További szerzők:	Balogh Ágnes (1984-) (kardiológus) Csanádi Zoltán (1960-) (kardiológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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