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001-es BibID:	BIBFORM105955
Első szerző:	Fiatal Szilvia (epidemiológus, népegészségügyi szakember)
Cím:	Using SNP-based risk estimates in identification of susceptibility to cardiovascular diseases / S. Fiatal, P. Pikó, R. Ádány
Dátum:	2018
ISSN:	1101-1262
Megjegyzések:	Background: Common cardiovascular disorders (CVDs) result from a combination of genetic and environmental factors. Advances in genomics have fostered huge expectations about use of susceptibility variants for prevention, diagnosis, and treatment. We summarized the developments in the field from a public health perspective focusing on the applicability of data on single-nucleotide polymorphisms (SNPs). Methods: Systematic review was performed according to the PRISMA statement using PubMed, Embase, CINAHL, and Web of Science databases. Final records were structured based on main public health domains (prevention, early detection, and treatment) using a four-phase framework suggested for translational research: T1. From gene discovery to candidate health applications; T2. From health application to evidence based practice guidelines; T3. From evidence-based practice guidelines to health practice; T4. From practice to population health impacts. Results: Majority of research belongs to the T1 phase, there are only a few population-based impacts estimated. Studies suggest that a single SNP is a poor estimator of risk, but an individual's genetic profile combined with non-genetic factors better predict CVD risk among certain patient subgroups. More research is needed to validate whether these genomic profiles can prospectively identify individuals at risk to develop CVDs. Research gaps were identified: little information is available on studies suggesting ♭♭Health application to evidence-based practice guidelines''; no study is available on ♭♭Guidelines to health practice.'' It was not possible to identify studies that incorporate environmental or lifestyle factors in the risk estimation. Conclusions: Identifying populations have larger risk of developing common CVDs may result in personalized prevention programs by reducing people's risk of onset or disease progression. However, limited evidence is available on the application of genomic results in health or public health practice.
Tárgyszavak:	Orvostudományok Egészségtudományok konferenciacikk folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 28 : suppl4 (2018), p. 398. -
További szerzők:	Pikó Péter (1987-) (biológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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