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001-es BibID:	BIBFORM105973
Első szerző:	Soltész Beáta (molekuláris biológus)
Cím:	Representation of hypertension related polymorphisms in the Hungarian general and Roma populations / B. Soltész, Sz. Fiatal, Zs. Kósa, J. Sándor, R. Ádány
Dátum:	2016
ISSN:	1101-1262
Megjegyzések:	Background Roma represents the largest minority population in Europe. It was recently pointed out that the prevalence of hypertension is lower among the Roma compared to the majority population ever tested. Concerning the fact that hypertension is known to be highly affected by inheritable factors, our aim was to identify whether genetic factors contribute to the lower prevalence of hypertension. Methods SNPs (N = 23) related to renin-angiotensin-aldosterone system (AGT, CYP11, AGTR1, ACE), regulation of vascular tone (NOS3) and renal tubular sodium reabsorption (ADD1, NPPA), and homocysteine metabolism (MTHFR) previously described to be closely related to hypertension were investigated in representative random samples of the Hungarian Roma and general populations (N = 1202, N = 1167, respectively). Differences in allele frequencies, as well as genetic risk scores both unweighted (GRS) and weighted (wGRS) were defined for the study groups compared to estimate the joint effect of SNPs. 9th European Public Health Conference: Parallel Sessions 215 Downloaded from https://academic.oup.com/eurpub/article/26/suppl_1/ckw170.025/2448813 by School of Public Health user on 13 December 2022 Results Differences in allele frequencies between the study populations were significant in case of 7 polymorphisms after multiple test correction, and almost all susceptible alleles were more prevalent in the general population. The mean of GRSs was 19.6 3.1 SD in the Roma population while it was 20.4 3.2 SD in the general group (p < 0.01). Twenty-four % of Roma subject were in the bottom fifth of the GRS (GRS 17) compared with 18% of those in the general population while only 9% of Roma people were in the top fifth (GRS 24) of the GRS compared with 17% of those in the general population (p < 0.001). In addition, the mean wGRS was significantly lower in the subjects of Roma population comparing to the subjects of general population (0.5 vs. 0.6, p < 0.01). Conclusions GRS modelling showed lower burden of risk alleles for hypertension in Roma compared to Hungarian general population, suggesting ethnicity-related differences in genetic architecture underlying lower hypertension prevalence among Roma.
Tárgyszavak:	Orvostudományok Egészségtudományok konferenciacikk folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 26 : suppl1 (2016), p. 215-216. -
További szerzők:	Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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