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001-es BibID:	BIBFORM105981
035-os BibID:	(cikkazonosító)2035 (Scopus)85144696494 (WoS)000901241100001
Első szerző:	Jenei Csaba (kardiológus)
Cím:	Novel Method to Detect Pitfalls of Intracoronary Pressure Measurements by Pressure Waveform Analysis / Jenei Csaba, Tar Balázs, Ágoston András, Sánta Péter, Sánta János, Csippa Benjámin, Wéber Richárd, Gyürki Dániel, Halász Gábor, Szabó Gábor Tamás, Czuriga Dániel, Kőszegi Zsolt
Dátum:	2022
ISSN:	2075-4426
Megjegyzések:	Potential pitfalls of fractional flow reserve (FFR) measurements are well-known drawbacks of invasive physiology measurement, e.g., significant drift of the distal pressure trace may lead to the misclassification of stenoses. Thus, a simultaneous waveform analysis of the pressure traces may be of help in the quality control of these measurements by online detection of such artefacts as the drift or the wedging of the catheter. In the current study, we analysed the intracoronary pressure waveform with a dedicated program. In 130 patients, 232 FFR measurements were performed and derivative pressure curves were calculated. Local amplitude around the dicrotic notch was calculated from the distal intracoronary pressure traces (?dPn/dt). A unidimensional arterial network model of blood flow was employed to simulate the intracoronary pressure traces at different flow rates. There was a strong correlation between ?dPn/dt values measured during hyperaemia and FFR (r = 0.88). Diagnostic performance of distal ?dPn/dt ? 3.52 for the prediction of FFR ? 0.80 was 91%. The correlation between the pressure gradient and the corresponding ?dPn/dt values obtained from all measurements independently of the physiological phase was also significant (r = 0.80). During simulation, the effect of flow rate on ?dPn/dt further supported the close correlation between the pressure ratios and ?dPn/dt. Discordance between the FFR and the ?dPn/dt can be used as an indicator of possible technical problems of FFR measurements. Hence, an online calculation of the ?dPn/dt may be helpful in avoiding some pitfalls of FFR evaluation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Personalized Medicine. - 12 : 12 (2022), p. 1-9. -
További szerzők:	Tar Balázs (1970-) (orvos) Ágoston András Sánta Péter Sánta János (orvos) Csippa Benjamin Wéber Richárd Gyürki Dániel Halász Gábor J. (1961-) (fizikus) Szabó Gábor Tamás (1982-) (kardiológus) Czuriga Dániel (1982-) (kardiológus) Kőszegi Zsolt (1962-) (kardiológus, belgyógyász)
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