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001-es BibID:	BIBFORM106367
035-os BibID:	(cikkazonosító)389 (scopus)85126609863 (wos)000775439000001
Első szerző:	Bene László (biofizikus)
Cím:	T-cell receptor is a threshold detector : sub- and supra-threshold stochastic resonance in TCR-MHC clusters on the cell surface / Bene László, Bagdány Miklós, Damjanovich László
Dátum:	2022
ISSN:	1099-4300
Megjegyzések:	Stochastic resonance in clusters of major histocompatibility molecules is extended by a more detailed description of adaptive thresholding and by applying the notion of suprathreshold stochastic resonance as a stochastically quantizing encoder of transmembrane signaling downstream of major histocompatibility molecules and T-cell receptors on the side of presenting and recognizing cells, respectively. The adaptive nature of thresholding is partly explained by a mirroring of the noncognate?cognate dichotomy shown by the T-cell receptor structure and the kinetic-segregation model of the onset of T-cell receptor triggering. Membrane clusters of major histocompatibility molecules and T-cell receptors on their host cells are envisioned as places of the temporal encoding of downstream signals via the suprathreshold stochastic resonance process. The ways of optimization of molecular prostheses, such as chimeric antigen receptors against cancer in transmembrane signaling, are suggested in the framework of suprathreshold stochastic resonance. The analogy between Förster resonance energy transfer and suprathreshold stochastic resonance for information transfer is also discussed. The overlap integral for energy transfer parallels the mutual information transferred by suprathreshold stochastic resonance.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk noncognate-cognate discrimination MHCI/MHCII TCR CD8/CD4 distributed signal detection chimeric antigen receptor (CAR) optimization mutual information correlation pattern recognition Förster resonance energy transfer (FRET)
Megjelenés:	Entropy. - 24 : 3 (2022), p. 1-21. -
További szerzők:	Bagdány Miklós Damjanovich László (1960-) (általános sebész)
Pályázati támogatás:	1G3DBLR0TUDF-247 Egyéb OSTRAT/810/213 Egyéb TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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