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001-es BibID:	BIBFORM106383
035-os BibID:	(cikkazonosító)105 (scopus)85040571262 (wos)000419658100005
Első szerző:	Fellows, Rachel
Cím:	Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases / Fellows Rachel, Denizot Jérémy, Stellato Claudia, Cuomo Alessandro, Jain Payal, Stoyanova Elena, Balázsi Szabina, Hajnády Zoltán, Liebert Anke, Kazakevych Juri, Blackburn Hector, Correa Renan Oliveira, Fachi José Luís, Sato Fabio Takeo, Ribeiro Willian R., Ferreira Caroline Marcantonio, Perée Hélene, Spagnuolo Mariangela, Mattiuz Raphaël, Matolcsi Csaba, Guedes Joana, Clark Jonathan, Veldhoen Marc, Bonaldi Tiziana, Vinolo Marco Aurélio Ramirez, Varga-Weisz Patrick
Dátum:	2018
ISSN:	2041-1723
Megjegyzések:	The recently discovered histone post-translational modification crotonylation connects cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly understood. We characterize histone crotonylation in intestinal epithelia and find that histone H3 crotonylation at lysine 18 is a surprisingly abundant modification in the small intestine crypt and colon, and is linked to gene regulation. We show that this modification is highly dynamic and regulated during the cell cycle. We identify class I histone deacetylases, HDAC1, HDAC2, and HDAC3, as major executors of histone decrotonylation. We show that known HDAC inhibitors, including the gut microbiota-derived butyrate, affect histone decrotonylation. Consistent with this, we find that depletion of the gut microbiota leads to a global change in histone crotonylation in the colon. Our results suggest that histone crotonylation connects chromatin to the gut microbiota, at least in part, via short-chain fatty acids and HDACs.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Nature Communications. - 9 : 1 (2018), p. 1-15. -
További szerzők:	Denizot, Jérémy Stellato, Claudia Cuomo, Alessandro Jain, Payal Stoyanova, Elena Balázsi Szabina Hajnády Zoltán (1991-) (biomérnök, biokémikus) Liebert, Anke Kazakevych, Juri Blackburn, Hector Correa, Renan Oliveira Fachi, José Luís Sato, Fabio Takeo Ribeiro, Willian R. Ferreira, Caroline Marcantonio Perée, Hélene Spagnuolo, Mariangela Mattiuz, Raphaël Matolcsi Csaba Guedes, Joana Clark, Jonathan Veldhoen, Marc Bonaldi, Tiziana Vinolo, Marco Aurélio Ramirez Varga-Weisz Patrick
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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