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001-es BibID:	BIBFORM107291
035-os BibID:	(WoS)000831383500001 (Scopus)85133226070
Első szerző:	Kuki Ákos (villamosmérnök)
Cím:	Quantification of Polyethylene Glycol 400 Excreted in the Urine by MALDI-TOF Mass Spectrometry / Ákos Kuki, Mahir Hashimov, Tibor Nagy, Csaba Tóth, Miklós Zsuga, Sándor Kéki
Dátum:	2022
ISSN:	1999-4923
Megjegyzések:	Polyethylene glycol 400 (PEG 400) was used as a permeability probe to examine the gastrointestinal tract which can be involved in the pathogenesis of some inflammatory and autoimmune diseases. A novel methodology was developed and validated for the quantitation of PEG 400 excreted in human urine after oral administration using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). The excretion ratios were determined for the most intense ions corresponding to nine PEG 400 oligomers. The relative error of accuracy was between ?6.0% and 8.5%, and the relative standard deviation (RSD) of the precision was below 15%. Our method was successfully applied in a large-scale experimental study involving nearly two hundred volunteers. Due to the large number of measurements, detailed and reliable statistical analysis was performed. No significant difference was found between the male and female group of volunteers at 0.05 significance level, except the two largest PEG oligomers. However, the average excretion ratios of the male volunteers are greater than that of the women for all the nine PEG oligomers, suggesting a difference in the intestinal permeability between men and women.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pharmaceutics. - 14 : 7 (2022), p. 1341-1353. -
További szerzők:	Hashimov, Mahir (1991-) (chemist) Nagy Tibor (1988-) (vegyész) Tóth Csaba Zsuga Miklós (1944-) (polimer kémikus) Kéki Sándor (1964-) (polimer kémikus)
Pályázati támogatás:	TKP2021-EGA-20 Egyéb GINOP-2.3.3-15-2016-00021 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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