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001-es BibID:	BIBFORM108315
035-os BibID:	(Scopus)33846861493 (WOS)000244064000028
Első szerző:	Pel, Herman J.
Cím:	Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 / Herman J. Pel, Johannes H. de Winde, David B. Archer, Paul S. Dyer, Gerald Hofmann, Peter J. Schaap, Geoffrey Turner, Ronald P. de Vries, Richard Albang, Kaj Albermann, Mikael R. Andersen, Jannick D. Bendtsen, Jacques A. E. Benen, Marco van den Berg, Stefaan Breestraat, Mark X. Caddick, Roland Contreras, Michael Cornell, Pedro M. Coutinho, Etienne G. J. Danchin, Alfons J. M. Debets, Peter Dekker, Piet W. M. van Dijck, Alard van Dijk, Lubbert Dijkhuizen, Arnold J. M. Driessen, Christophe d'Enfert, Steven Geysens, Coenie Goosen, Gert S. P. Groot, Piet W. J. de Groot, Thomas Guillemette, Bernard Henrissat, Marga Herweijer, Johannes P. T. W. van den Hombergh, Cees A. M. J. J. van den Hondel, Rene T. J. M. van der Heijden, Rachel M. van der Kaaij, Frans M. Klis, Harrie J. Kools, Christian P. Kubicek, Patricia A. van Kuyk, Jürgen Lauber, Xin Lu, Marc J. E. C. van der Maarel, Rogier Meulenberg, Hildegard Menke, Martin A. Mortimer, Jens Nielsen, Stephen G. Oliver, Maurien Olsthoorn, Karoly Pal, Noël N. M. E. van Peij, Arthur F. J. Ram, Ursula Rinas, Johannes A. Roubos, Cees M. J. Sagt, Monika Schmoll, Jibin Sun, David Ussery, Janos Varga, Wouter Vervecken, Peter J. J. van de Vondervoort, Holger Wedler, Han A. B. Wösten, An-Ping Zeng, Albert J. J. van Ooyen, Jaap Visser, Hein Stam
Dátum:	2007
ISSN:	1087-0156
Megjegyzések:	The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Nature Biotechnology. - 25 : 2 (2007), p. 221-231. -
További szerzők:	Winde, Johannes H. de Archer, David Dyer, Paul S. Hofmann, Gerald Schaap, Peter J. Turner, Geoffrey De Vries, Ronald P. Albang, Richard Albermann, Kaj Andersen, Mikael R. Bendtsen, Jannick D. Benen, Jacques A. E. Berg, Marco van den Breestraat, Stefaan Caddick, Mark X. Contreras, Roland Cornell, Michael J. Coutinho, Pedro M. Danchin, Etienne G. J. Debets, Alfons J. M. Dekker, Peter Dijck, Piet W. M. van Dijk, Alard van Dijkhuizen, Lubbert Driessen, Arnold J. M. d'Enfert, Christophe Geysens, Steven Goosen, Coenie Groot, Gert S. P. Groot, Piet W. J. de Guillemette, Thomas Henrissat, Bernard Herweijer, Marga Hombergh, Johannes P. T. W. van den Hondel, Cees A. M. J. J. van den Heijden, Rene T. J. M. van der Kaaij, Rachel M. van der Klis, Frans M. Kools, Harrie J. Kubicek, Christian P. Kuyk, Patricia A. van Lauber, Jürgen Lu, Xin Maarel, Marc J. E. C. van der Meulenberg, Rogier Menke, Hildegard Mortimer, Martin A. Nielsen, Jens Oliver, Stephen G. Olsthoorn, Maurien Pál Károly (1978-) (mikrobiológus) Peij, Noël N. M. E. van Ram, Arthur F.J. Rinas, Ursula Roubos, Johannes A. Sagt, Cees M. J. Schmoll, Monika Sun, Jibin Ussery, Dave Varga János Vervecken, Wouter Vondervoort, Peter J. I. van de Wedler, Holger Wösten, Han A. B. Zeng, An Ping Ooyen, Albert J. J. van Visser, Jaap Stam, Hein
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