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001-es BibID:	BIBFORM108902
035-os BibID:	(cikkazonosító)102617 (scopus)85148306870 (WoS)000935285300001 (Pubmed)36738685
Első szerző:	Domán Andrea
Cím:	Interactions of reactive sulfur species with metalloproteins / Domán Andrea, Dóka Éva, Garai Dorottya, Bogdándi Virág, Balla György, Balla József, Nagy Péter
Dátum:	2023
ISSN:	2213-2317
Megjegyzések:	Reactive sulfur species (RSS) entail a diverse family of sulfur derivatives that have emerged as important effector molecules in H2S-mediated biological events. RSS (including H2S) can exert their biological roles via widespread interactions with metalloproteins. Metalloproteins are essential components along the metabolic route of oxygen in the body, from the transport and storage of O2, through cellular respiration, to the maintenance of redox homeostasis by elimination of reactive oxygen species (ROS). Moreover, heme peroxidases contribute to immune defense by killing pathogens using oxygen-derived H2O2 as a precursor for stronger oxidants. Coordination and redox reactions with metal centers are primary means of RSS to alter fundamental cellular functions. In addition to RSS-mediated metalloprotein functions, the reduction of high-valent metal centers by RSS results in radical formation and opens the way for subsequent per-and polysulfide formation, which may have implications in cellular protection against oxidative stress and in redox signaling. Furthermore, recent findings pointed out the potential role of RSS as substrates for mitochondrial energy production and their cytoprotective capacity, with the involvement of metalloproteins. The current review summarizes the interactions of RSS with protein metal centers and their biological implications with special emphasis on mechanistic aspects, sulfide-mediated signaling, and pathophysiological consequences. A deeper understanding of the biological actions of reactive sulfur species on a molecular level is primordial in H2S-related drug development and the advancement of redox medicine.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Hydrogen sulfide Reactive sulfur species Metalloprotein Heme Oxidative stress
Megjelenés:	Redox Biology. - 60 (2023), p. 1-25. -
További szerzők:	Dóka Éva (1988-) (vegyész) Garai Dorottya (1989-) (biológus) Bogdándi Virág Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Balla József (1959-) (belgyógyász, nephrológus) Nagy Péter (1976-) (vegyész)
Pályázati támogatás:	OTKA-132828 OTKA TKP2020-NKA-04 Egyéb TKP2021-EGA-18 Egyéb 2022-2.1.1-NL-2022-00010 Egyéb TKP2021-EGA-44 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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