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001-es BibID:	BIBFORM109123
035-os BibID:	(cikkazonosító)4566 (WoS)000947319300001 (Scopus)85149877208
Első szerző:	Pikó Péter (biológus)
Cím:	Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations / Pikó Péter, Bácsné Bába Éva, Kósa Zsigmond, Sándor János, Kovács Nóra, Bács Zoltán, Ádány Róza
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12?1.97; p = 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16?1.70; p < 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGSRoma: 2.19 SD: 0.99 vs. oPGSHG: 2.70 SD: 1.06; p < 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk genetics leisure-time physical activity polygenic score Roma population Hungarian population
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 5 (2023), p. 1-14. -
További szerzők:	Bácsné Bába Éva (1968-) (bölcsésztanár, szakközgazda) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Bács Zoltán (1969-) (agrármérnök) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2- 15-2016-00005 Egyéb TK2016-78 Egyéb TKCS-2021/32 Egyéb 135784 OTKA ÚNKP-22-4-II-DE-268 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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