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001-es BibID:	BIBFORM109964
035-os BibID:	(scopus)85148082398 (wos)000935540500006
Első szerző:	Maamrah, Baneen (molekuláris biológus)
Cím:	KCNQ4 potassium channel subunit deletion leads to exaggerated acoustic startle reflex in mice / Maamrah Baneen, Pocsai Krisztina, Bayasgalan Tsogbadrakh, Csemer Andrea, Pál Balázs
Dátum:	2023
ISSN:	0959-4965
Megjegyzések:	The potassium voltage-gated channel subfamily Q member 4 (KCNQ4) subunit forms channels responsible for M-current, a muscarine-sensitive potassium current regulating neuronal excitability. In contrast to other KCNQ subunits, its expression is restricted to the cochlear outer hair cells, the auditory brainstem and other brainstem nuclei in a great overlap with structures involved in startle reflex. We aimed to show whether startle reflexis affected by the loss of KCNQ4 subunit and whether these alterations are similar to the ones caused by brainstem hyperexcitability. Young adult KCNQ4 knockout mice and wild-type littermates, as well as mice expressing hM3D chemogenetic actuator in the pontine caudal nucleus and neurons innervating it were used for testing acoustic startle. The acoustic startle reflex was significantly increased in knockout mice compared with wild-type littermates. When mice expressing human M3 muscarinic (hM3D) in nuclei related to startle reflex were tested, a similar increase of the first acoustic startle amplitude and a strong habituation of the further responses was demonstrated. We found that the acoustic startle reflex is exaggerated and minimal habituation occurs in KCNQ4 knockout animals. These changes are distinct from the effects of the hyperexcitability of nuclei involved in startle. One can conclude that the exaggerated startle reflex found with the KCNQ4 subunit deletion is the consequence of both the cochlear damage and the changes in neuronal excitability of startle networks.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Neuroreport. - 34 : 4 (2023), p. 232-237. -
További szerzők:	Pocsai Krisztina (1978-) (élettanász) Bayasgalan, Tsogbadrakh (1983-) (Általános orvos) Csemer Andrea (1994-) (molekuláris biológus) Pál Balázs (1975-) (élettanász)
Pályázati támogatás:	TKP2020-NKA-04 Egyéb 2020-4.1.1-TKP2020 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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