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001-es BibID:	BIBFORM110889
035-os BibID:	(scopus)85075529322 (WOS)000497465600047
Első szerző:	Papp Gábor (belgyógyász)
Cím:	Immunomodulatory effects of regular physical exercise in older age / Papp Gábor, Szabó Krisztina, Jámbor Ilona, Mile Marianna, Csiki Zoltán, Balogh László
Dátum:	2019
ISSN:	0014-2980
Megjegyzések:	Background: Studies of the last decade revealed the important effects of physical activity on immune functions. These effects may largely depend on the type of activity, its intensity and duration. However, little information is available regarding the immunological effects of sporting activities in older age. The aim of our study was to examine the changes in a wide spectrum of lymphocyte subtypes after a period of regular workout among healthy elderly women. Method: In our study, we enrolled 16 elderly women (between ages of 60-75 years) not engaged in regular physical activity. Additionally, as young controls, we enrolled 26 young adult women (between ages of 19-23 years), who were not engaged in regular physical activity. The group of elderly women completed a 6-week lightweight conditioning gymnastic exercise program. The percentages of peripheral natural killer (NK), NKT cells, T and B lymphocyte subtypes (early-/late activated T, naive and memory T, cytotoxic T (Tc), T-helper (Th)1, Th2, Th17, T regulatory type 1 (Tr1), CD4+CD127- CD25bright Treg, as well as naive and memory B cells) were determined by flow cytometry. Results: Regarding the baseline values, in the elderly women, levels of CD3+6B11+ NKT cells were lower, while ratios of CD4+ Th/CD8+ Tc cells were higher compared to the values of younger individuals. At the end of exercise program, pronounced changes were observed in elderly women: percentages of IgD+ naive B cells decreased, while levels of CD27+ switched-memory B cells increased. Furthermore, proportions of CD4+IL-4+ Th2 cells increased, while levels of immunosuppressive CD4+CD127-CD25 bright Treg cells decreased following the regular exercise workout. Conclusion: Differences observed after the regular lightweight exercise program reflect a presumably enhanced immunoreactivity and increased ability for immune responses.
Tárgyszavak:	Orvostudományok Sporttudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal of Immunology. - 49 : Suppl. 4 (2019), p. 50. -
További szerzők:	Szabó Krisztina (1987-) (Molekuláris biológus) Jámbor Ilona (1985-) (orvosi biotechológus) Mile Marianna (1977-) (gyógytornász) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Balogh László (1976-) (sporttudomány)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00062 GINOP Bolyai János Kutatási Ösztöndíj Egyéb Új Nemzeti Kiválóság Program 19-4 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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