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001-es BibID:	BIBFORM110898
035-os BibID:	(cikkazonosító)1218 (WoS)000977128900001 (Scopus)85153720382
Első szerző:	Nagy Nikolett (belgyógyász)
Cím:	Changes in Clinical Manifestations and Course of Systemic Lupus Erythematosus and Secondary Antiphospholipid Syndrome over Three Decades / Nagy Nikolett, Papp Gábor, Gáspár-Kiss Eszter, Diószegi Ágnes, Tarr Tünde
Dátum:	2023
ISSN:	2227-9059
Megjegyzések:	Systemic lupus erythematosus (SLE) is often associated with antiphospholipid syndrome (APS), which potentially results in a more severe disease course and reduced life expectancy. Since the therapeutic guidelines have been refined in the last 15 years, we assumed that the diseases course has become more favorable. In order to shed light on these achievements, we compared the data of SLE patients diagnosed before and since 2004. In our retrospective study, we assessed a wide spectrum of clinical and laboratory data of 554 SLE patients who received regular follow-up care and therapy at our autoimmune center. Among these patients, 247 had antiphospholipid antibodies (APAs) without clinical signs of APS, and 113 had definitive APS. In the APS group, among patients diagnosed since 2004, deep vein thrombosis (p = 0.049) and lupus anticoagulant positivity (p = 0.045) were more frequent, while acute myocardial infarction was less frequent (p = 0.021) compared with patients diagnosed before 2004. Among the APA positive patients without definitive APS, anti-cardiolipin antibody positivity (p = 0.024) and development of chronic renal failure (p = 0.005) decreased in patients diagnosed since 2004. Our study demonstrates that the disease course has changed in recent years; however, in the presence of APS, we have to expect repeated thrombotic events despite adequate anticoagulant therapy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk systemic lupus erythematosus antiphospholipid syndrome disease course therapy
Megjelenés:	Biomedicines. - 11 : 4 (2023), p. 1-10. -
További szerzők:	Papp Gábor (1984-) (belgyógyász) Gáspár-Kiss Eszter (1997-) (rezidens) Diószegi Ágnes (1987-) (belgyógyász) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus)
Pályázati támogatás:	K 124177 NKFIH
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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