Találati lista | Tudóstér

001-es BibID:	BIBFORM110979
035-os BibID:	(cikkazonosító)4556 (wos)000947732900001 (scopus)85149978403
Első szerző:	Ghaffarinia, Ameneh
Cím:	Psoriatic Resolved Skin Epidermal Keratinocytes Retain Disease-Residual Transcriptomic and Epigenomic Profiles / Ghaffarinia Ameneh, Ayaydin Ferhan, Póliska Szilárd, Manczinger Máté, Bolla Beáta Szilvia, Flink Lili Borbála, Balogh Fanni, Veréb Zoltán, Bozó Renáta, Szabó Kornélia, Bata-Csörgő Zsuzsanna, Kemény Lajos
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Abstract: The disease-residual transcriptomic profile (DRTP) within psoriatic healed/resolved skin and epidermal tissue-resident memory T (TRM) cells have been proposed to be crucial for the recurrence of old lesions. However, it is unclear whether epidermal keratinocytes are involved in disease recurrence. There is increasing evidence regarding the importance of epigenetic mechanisms in the pathogenesis of psoriasis. Nonetheless, the epigenetic changes that contribute to the recurrence of psoriasis remain unknown. The aim of this study was to elucidate the role of keratinocytes in psoriasis relapse. The epigenetic marks 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) were visualized using immunofluorescence staining, and RNA sequencing was performed on paired never-lesional and resolved epidermal and dermal compartments of skin from psoriasis patients. We observed diminished 5-mC and 5-hmC amounts and decreased mRNA expression of the ten-eleven translocation (TET) 3 enzyme in the resolved epidermis. SAMHD1, C10orf99, and AKR1B10: the highly dysregulated genes in resolved epidermis are known to be associated with pathogenesis of psoriasis, and the DRTP was enriched in WNT, TNF, and mTOR signaling pathways. Our results suggest that epigenetic changes detected in epidermal keratinocytes of resolved skin may be responsible for the DRTP in the same regions. Thus, the DRTP of keratinocytes may contribute to site-specific local relapse.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk psoriasis keratinocyte relapse transcriptomics epigenomics 5-mC 5-hmC
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 5 (2023), p. 1-20. -
További szerzők:	Ayaydin, Ferhan Póliska Szilárd (1978-) (biológus) Manczinger Máté Bolla Beáta Szilvia Flink Lili Borbála Balogh Fanny (1995-) (hallgató) Veréb Zoltán (1980-) (immunológus, mikrobiológus, molekuláris biológus) Bozó Renáta Szabó Kornélia Bata-Csörgő Zsuzsanna Kemény Lajos V. (bőrgyógyász Szeged)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: