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001-es BibID:	BIBFORM111149
035-os BibID:	(cikkazonosító)122978 (WoS)001004374000001 (Scopus)85159054100
Első szerző:	Képes Zita (orvos)
Cím:	Insights into recent preclinical studies on labelled cyclodextrin-based imaging probes : towards a novel oncological era / Képes Zita, Hajdu István, Fenyvesi Ferenc, Trencsényi György
Dátum:	2023
ISSN:	0378-5173
Megjegyzések:	As malignancies remain one of the major health concerns worldwide, increasing focus has been centered around the application of cyclodextrins (CDs) in cancer imaging and therapy due to their outstanding inclusion forming capability. Albeit the physicochemical properties of CDs were intensively elucidated, the spread of their clinical application is limited by the relative paucity of knowledge about their pharmacokinetic profile, especially biodistribution. Studies applying fluorescently- CDs, or CD-based MRI contrast agents revealed much about pharmacokinetics and diagnostic applications; however, derivatives labelled with positron emitters seem superior molecular probes in the investigation of the route of CDs in biological niche. In vivo imaging based on preclinical tumor-bearing model systems are well-suited to evaluate the whole-body distribution of the two most frequently assessed CDs: randomly methylated ?-cyclodextrin (RAMEB), and hydroxypropyl-?-cyclodextrin (HPBCD). Exploiting the firm signaling interaction between cancer-related cyclooxygenase-2, prostaglandin E2 (PGE2) and RAS oncoprotein, radioconjugated, PGE2-affine CDs project the establishment of novel imaging probes and therapeutic agents. Currently, we provide an overview of the preclinical studies on CD pharmacokinetics highlighting the significance of the integration of translational discoveries into human patient care.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk carcinogenesis cyclodextrins (CDs) in vivo pharmacokinetics positron emission tomography (PET) radiolabelling
Megjelenés:	International Journal Of Pharmaceutics. - 640 (2023), p. 1-12. -
További szerzők:	Hajdu István (1981-) (vegyész) Fenyvesi Ferenc (1977-) (gyógyszerész, gyógyszertechnológus) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus)
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