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001-es BibID:	BIBFORM112758
035-os BibID:	(cikkazonosító)3223 (WoS)001014297900001 (Scopus)85163858584
Első szerző:	Bicskó Réka Ráhel (általános orvos)
Cím:	Autologous Transplantation May Still Effectively Treat Relapsed Diffuse Large B-Cell Lymphoma in Selected Patients / Bicsko Reka Rahel, Antal Lili, Magyari Ferenc, Szász Róbert, Udvardy Miklós, Illes Arpad, Gergely Lajos
Dátum:	2023
ISSN:	2072-6694
Megjegyzések:	Treating relapsed and refractory diffuse large B-cell lymphoma is still challenging for clinicians, but the available CAR-T and bispecific antibodies have revolutionized therapy. Autologous stem cell transplantation was the most effective treatment modality previously. The authors reported data from a single center over ten years. The retrospective study included 116 patients, with 53 relapsed cases, 39 primary refractory cases, 19 who had CNS involvement, and 5 who had received primary consolidation transplants. The median duration of follow-up was 46 months. The median event-free survival was 75 months, and the median overall survival was 105 months for all cases. Five-year overall survival was 59%, and event-free survival was 54%. Pretreatment prognostic factors at diagnosis had no effect on the outcome of transplantation. The authors found no difference between survival in relapsed or refractory cases, and the number of salvage lines or the germinal center/activated B-cell type also did not influence the results. Complete metabolic response before transplantation confirmed by 18FDG PET/CT strongly affected survival. The pre-transplant creatinine and CRP levels significantly influenced the long-term outcome. The number of stem cells infused did not affect survival, but engraftment within nine days did result in a longer survival. These data support the finding that the response to salvage therapy did facilitate the identification of a better prognostic group who may still benefit from autologous transplantation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Cancers. - 15 : 12 (2023), p. 1-12. -
További szerzők:	Antal Lili Magyari Ferenc (1985-) (belgyógyász, hematológus) Szász Róbert (1972-) (belgyógyász, haematológus) Udvardy Miklós (1947-) (belgyógyász, haematológus) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Gergely Lajos (1965-) (belgyógyász, haematológus)
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