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001-es BibID:	BIBFORM112811
035-os BibID:	(cikkazonosító)321 (WoS)001016138200002 (Scopus)85163149718
Első szerző:	Takács Péter (szülész-nőgyógyász)
Cím:	A randomized controlled pilot trial to assess the effectiveness of a specially formulated food supplement and pelvic floor muscle training in women with stress-predominant urinary incontinence / Takacs Peter, Pákozdy Krisztina, Koroknai Erzsébet, Erdődi Balázs, Krasznai Zoárd, Kozma Bence
Dátum:	2023
ISSN:	1472-6874
Megjegyzések:	Background: Pelvic floor muscle training (PFMT) is the first-line treatment approach for stress urinary incontinence. Creatine and leucine have been shown to improve muscle function. Our aim was to assess the effectiveness of a food supplement and PFMT in women with stress-predominant urinary incontinence. Methods: Women with stress-predominant urinary incontinence were randomized in 1:1 ratio to receive daily oral supplementation for six weeks with either a food supplement (treatment group) or placebo (control group). Both groups were instructed to perform standardized daily PFMT. The primary outcome was the Urogenital Distress Inventory Short Form (UDI-6) score. Secondary outcomes were the Incontinence Impact Questionnaire (IIQ?7) score, Patient's Global Impression of Severity (PGI?S), and Biomechanical Integrity score (BI-score) measured by Vaginal Tactile Imager. To have a power of 80% and a significance level of 5% to detect a decrease of 16 points in the UDI-6 score, a sample size of 32 was needed, with 16 patients in each arm of our trial. Results: Sixteen women in the control group and sixteen in the treatment group completed the trial. Between-group analysis revealed no significant differences between the control and treatment group except for mean change (delta) in vaginal squeeze pressure [(cmH2O, mean?SD), 5?12 vs. 15?15, P=0.04] and mean change (delta) in PGI-S score [(mean ? SD), -0.2?0.9 vs. -0.8?0.8, P=0.04]. Within-group analysis showed that UDI-6 and IIQ-7 scores improved significantly from baseline to six weeks in the treatment group but not in the control group [UDI-6 score (mean?SD) 45?21 vs. 29?21, P=0.02; 43?18 vs. 33?26, P=0.22] [IIQ-7 score (mean?SD) 50?30 vs. 30?21, P=0.01; 48?23 vs.40?28, P=0.36]. PGI-S scores only improved in the treatment group from baseline to six weeks after treatment [PGI-S score (mean?SD) 3.1?0.8 vs. 2.3?0.8, P=0.0001]. BI-score, on average, improved significantly in the treatment and control group as well [SD unit, mean, from -1.06 to -0.58, P=0.001; from -0.66 to -0.42, P=0.04]. Conclusions: Women with stress-predominant urinary incontinence receiving a specially formulated supplement in addition to daily PFMT for six weeks had significantly improved urinary symptoms (decrease in UDI-6 score and IIQ-7) and BI-score compared to their baseline.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk urinary incontinence Pelvic floor Creatine Zinc Leucine
Megjelenés:	BMC Womens Health. - 23 : 1 (2023), p. 1-12. -
További szerzők:	Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Koroknai Erzsébet (1987-) (szülész-nőgyógyász) Erdődi Balázs (1984-) (szülész-nőgyógyász szakorvosjelölt) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
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