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001-es BibID:	BIBFORM112826
035-os BibID:	(cikkazonosító)15 (scopus)85147393025 (wos)000926120000002
Első szerző:	Nĕmejcová, Kristýna
Cím:	A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors / Nemejcová Kristyna, Bártu Michaela Kendall, Michálková Romana, Drozenová Jana, Fabian Pavel, Fadare Oluwole, Hausnerová Jitka, Laco Jan, Matej Radoslav, Méhes Gábor, Singh Naveena, Stolnicu Simona, Skapa Petr, Svajdler Marián, Struzinská Ivana, Cibula David, Kocian Roman, Lax Sigurd F., McCluggage W. Glenn, Dundr Pavel
Dátum:	2023
ISSN:	1746-1596
Megjegyzések:	Background: IMP2 and IMP3 are mRNA binding proteins involved in carcinogenesis. We examined a large cohort of ovarian tumors with the aim to assess the value of IMP2 and IMP3 for differential diagnosis, and to assess their prognostic significance. Methods: Immunohistochemical analyses with antibodies against IMP2 and IMP3 were performed on 554 primary ovarian tumors including 114 high grade serous carcinomas, 100 low grade serous carcinomas, 124 clear cell carcinomas, 54 endometrioid carcinomas, 34 mucinous carcinomas, 75 mucinous borderline tumors, and 41 serous border- line tumors (micropapillary variant). The associations of overall positivity with clinicopathological characteristics were evaluated using the chi-squared test or Fisher's Exact test. Results: We found IMP2 expression (in more than 5% of tumor cells) in nearly all cases of all tumor types, so the prognostic meaning could not be analyzed. The positive IMP3 expression (in more than 5% of tumor cells) was most common in mucinous carcinomas (82%) and mucinous borderline tumors (81%), followed by high grade serous (67%) and clear cell carcinomas (67%). The expression was less frequent in endometrioid carcinomas (39%), low grade serous carcinomas (23%), and micropapillary variant of serous borderline tumors (20%). Prognostic significance of IMP3 could be evaluated only in low grade serous carcinomas in the case of relapse-free survival, where negative cases showed better RFS (p = 0.033). Conclusion: Concerning differential diagnosis our results imply that despite the differences in expression in the different ovarian tumor types, the practical value for diagnostic purposes is limited. Contrary to other solid tumors, we did not find prognostic significance of IMP3 in ovarian cancer, with the exception of RFS in low grade serous carcinomas. However, the high expression of IMP2 and IMP3 could be of predictive value in ovarian carcinomas since IMP proteins are potential therapeutical targets.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Diagnostic Pathology. - 18 : 1 (2023), p. 1-10. -
További szerzők:	Bártủ, Michaela Michálková, Romana Drozenová, Jana Fabian, Pavel Fadare, Oluwole Hausnerová, Jitka Laco, Jan Matej, Radoslav Méhes Gábor (1966-) (patológus) Singh, Naveena Stolnicu, Simona Škapa, Petr Svajdler, Marián Struzinská, Ivana Cibula, David Kocian, Roman Lax, Sigurd F. McCluggage, W. Glenn Dundr, Pavel
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