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001-es BibID:	BIBFORM113381
035-os BibID:	(Scopus)85147536569 (WOS)000921214500001
Első szerző:	Bogani, Giorgio
Cím:	Endometrial carcinosarcoma / Bogani Giorgio, Ray-Coquard Isabelle, Concin Nicole, Ngoi Natalie Yan Li, Morice Philippe, Caruso Giuseppe, Enomoto Takayuki, Takehara Kazuhiro, Denys Hannelore, Lorusso Domenica, Coleman Robert, Vaughan Michelle M., Takano Masashi, Provencher Diane Michele, Sagae Satoru, Wimberger Pauline, Póka Robert, Segev Yakir, Kim Se Ik, Kim Jae-Weon, Candido dos Reis Francisco Jose, Ramirez Pedro T., Mariani Andrea, Leitao Mario, Makker Vicky, Abu-Rustum Nadeem R., Vergote Ignace, Zannoni Gianfranco, Tan David, McCormack Mary, Paolini Biagio, Bini Marta, Raspagliesi Francesco, Benedetti Panici Pierluigi, Di Donato Violante, Muzii Ludovico, Colombo Nicoletta, Pignata Sandro, Scambia Giovanni, Monk Bradley J.
Dátum:	2023
ISSN:	1048-891X
Megjegyzések:	Endometrial carcinosarcoma is a rare and aggressive high-grade endometrial carcinoma with secondary sarcomatous trans-differentiation (conversion theory). The clinical presentation and diagnostic work-up roughly align with those of the more common endometrioid counterpart, although endometrial carcinosarcoma is more frequently diagnosed at an advanced stage. Endometrial carcinosarcoma is not a single entity but encompasses different histological subtypes, depending on the type of carcinomatous and sarcomatous elements. The majority of endometrial carcinosarcomas are characterized by p53 abnormalities. The proportion of POLE and microsatellite instablity-high (MSI-H) is directly related to the epithelial component, being approximately 25% and 3% in endometrioid and non-endometrioid components.The management of non-metastatic disease is based on a multimodal approach with optimal surgery followed by (concomitant or sequential) chemotherapy and radiotherapy, even for early stages. Palliative chemotherapy is recommended in the metastatic or recurrent setting, with carboplatin/paclitaxel doublet being the first-line regimen. Although the introduction of immunotherapy plus/minus a tyrosine kinase inhibitor shifted the paradigm of treatment of patients with recurrent endometrial cancer, patients with endometrial carcinosarcoma were excluded from most studies evaluating single-agent immunotherapy or the combination. However, the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approved the use of pembrolizumab and lenvatinib in endometrial cancer (all histotypes) after progression on chemotherapy and single-agent immunotherapy in MSI-H cancers. In the era of precision medicine, emerging knowledge on molecular endometrial carcinosarcoma is opening new promising therapeutic options for more personalized treatment. The present review outlines state-of-the-art knowledge and future directions for patients with endometrial carcinosarcoma.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Carboplatin Carcinosarcoma Combined Modality Therapy Endometrial Neoplasms Female Humans Neoplasm Recurrence, Local Uterine Neoplasms
Megjelenés:	International Journal Of Gynecological Cancer. - 33 : 2 (2023), p. 147-174. -
További szerzők:	Ray-Coquard, Isabelle Concin, Nicole Ngoi, Natalie Y. L. Morice, Philippe Caruso, Giuseppe Enomoto, Takayuki Takehara, Kazuhiro Denys, Hannelore Lorusso, Domenica Coleman, Robert Vaughan, Michelle M. Takano, Masashi Provencher, Diane Sagae, Satoru Wimberger, Pauline Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Segev, Yakir Kim, Se Ik Kim, Jae Weon Candido dos Reis, Francisco J. Ramirez, Pedro T. Mariani, Andrea Leitao, Mario M. Makker, Vicky Abu-Rustum, Nadeem R. Vergote, Ignace Zannoni, Gian Franco Tan, David S. P. McCormack, Mary Paolini, Biagio Bini, Marta Raspagliesi, Francesco Benedetti Panici, Pierluigi Di Donato, Violante Muzii, Ludovico Colombo, Nicoletta Pignata, Sandro Scambia, Giovanni Monk, Bradley J.
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