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001-es BibID:	BIBFORM115267
035-os BibID:	(Scopus)85071741811 (WoS)000484406300004 (cikkazonosító)eaax6775
Első szerző:	Oláh Tamás (élettanász)
Cím:	Topographic modeling of early human osteoarthritis in sheep / Tamás Oláh, Jan Reinhard, Liang Gao, Sophie Haberkamp, Lars K. H. Goebel, Magali Cucchiarini, Henning Madry
Dátum:	2019
ISSN:	1946-6234
Megjegyzések:	Articular cartilage damage occurring during early osteoarthritis (OA) is a key event marking the development of the disease. Here, we modeled early human OA by gathering detailed spatiotemporal data from surgically induced knee OA development in sheep. We identified a specific topographical pattern of osteochondral changes instructed by a defined meniscal injury, showing that both cartilage and subchondral bone degeneration are initiated from the region adjacent to the damage. Alterations of the subarticular spongiosa arising locally and progressing globally disturbed the correlations of cartilage with subchondral bone seen at homeostasis and were indicative of disease progression. We validated our quantitative findings against human OA, showing a similar pattern of early OA correlating with regions of meniscal loss and an analogous late critical disturbance within the entire osteochondral unit. This translational model system can be used to elucidate mechanisms of OA development and provides a roadmap for investigating regenerative therapies.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Science Translational Medicine. - 11 : 508 (2019), p. eaax6775. -
További szerzők:	Reinhard, Jan Gao, Liang Haberkamp, Sophie Goebel, Lars Cucchiarini, Magali Madry, Henning
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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